Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.

The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related t...

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Autores principales:	Jonathan Abraham, Jo Ann Kwong, César G Albariño, Jiajie G Lu, Sheli R Radoshitzky, Jorge Salazar-Bravo, Michael Farzan, Christina F Spiropoulou, Hyeryun Choe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/beb879c296f74e959df4baba2bec631c
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spelling	oai:doaj.org-article:beb879c296f74e959df4baba2bec631c2021-11-25T05:47:08ZHost-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.1553-73661553-737410.1371/journal.ppat.1000358https://doaj.org/article/beb879c296f74e959df4baba2bec631c2009-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19343214/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related to the NW arenaviruses that cause hemorrhagic fevers. Here we show that pseudotyped viruses bearing the surface glycoprotein (GP) of AMAV or TCRV can infect cells using the TfR1 orthologs of several mammalian species, including those of their respective natural hosts, the small rodent Neacomys spinosus and the fruit bat Artibeus jamaicensis. Mutation of one residue in human TfR1 makes it a functional receptor for TCRV, and mutation of four residues makes it a functional receptor for AMAV. Our data support an in vivo role for TfR1 in the replication of most, if not all, NW clade B arenaviruses, and suggest that with modest changes in their GPs the nonpathogenic arenaviruses could use human TfR1 and emerge as human pathogens.Jonathan AbrahamJo Ann KwongCésar G AlbariñoJiajie G LuSheli R RadoshitzkyJorge Salazar-BravoMichael FarzanChristina F SpiropoulouHyeryun ChoePublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 4, p e1000358 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Jonathan Abraham Jo Ann Kwong César G Albariño Jiajie G Lu Sheli R Radoshitzky Jorge Salazar-Bravo Michael Farzan Christina F Spiropoulou Hyeryun Choe Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.
description	The ability of a New World (NW) clade B arenavirus to enter cells using human transferrin receptor 1 (TfR1) strictly correlates with its ability to cause hemorrhagic fever. Amapari (AMAV) and Tacaribe (TCRV), two nonpathogenic NW clade B arenaviruses that do not use human TfR1, are closely related to the NW arenaviruses that cause hemorrhagic fevers. Here we show that pseudotyped viruses bearing the surface glycoprotein (GP) of AMAV or TCRV can infect cells using the TfR1 orthologs of several mammalian species, including those of their respective natural hosts, the small rodent Neacomys spinosus and the fruit bat Artibeus jamaicensis. Mutation of one residue in human TfR1 makes it a functional receptor for TCRV, and mutation of four residues makes it a functional receptor for AMAV. Our data support an in vivo role for TfR1 in the replication of most, if not all, NW clade B arenaviruses, and suggest that with modest changes in their GPs the nonpathogenic arenaviruses could use human TfR1 and emerge as human pathogens.
format	article
author	Jonathan Abraham Jo Ann Kwong César G Albariño Jiajie G Lu Sheli R Radoshitzky Jorge Salazar-Bravo Michael Farzan Christina F Spiropoulou Hyeryun Choe
author_facet	Jonathan Abraham Jo Ann Kwong César G Albariño Jiajie G Lu Sheli R Radoshitzky Jorge Salazar-Bravo Michael Farzan Christina F Spiropoulou Hyeryun Choe
author_sort	Jonathan Abraham
title	Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.
title_short	Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.
title_full	Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.
title_fullStr	Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.
title_full_unstemmed	Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.
title_sort	host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade b arenaviruses.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/beb879c296f74e959df4baba2bec631c
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Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic new world clade B arenaviruses.

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