C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:beb8ddfc0b0b4b249f1fbb7841a7699b
record_format	dspace
spelling	oai:doaj.org-article:beb8ddfc0b0b4b249f1fbb7841a7699b2021-12-02T17:31:10ZC/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition10.1038/s41467-020-14556-x2041-1723https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14556-xhttps://doaj.org/toc/2041-1723In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.Ana Rita LourençoM. Guy RoukensDanielle SeinstraCynthia L. FrederiksCornelieke E. PalsStephin J. VervoortAndreia S. MargaridoJacco van RheenenPaul J. CofferNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ana Rita Lourenço M. Guy Roukens Danielle Seinstra Cynthia L. Frederiks Cornelieke E. Pals Stephin J. Vervoort Andreia S. Margarido Jacco van Rheenen Paul J. Coffer C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
description	In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
format	article
author	Ana Rita Lourenço M. Guy Roukens Danielle Seinstra Cynthia L. Frederiks Cornelieke E. Pals Stephin J. Vervoort Andreia S. Margarido Jacco van Rheenen Paul J. Coffer
author_facet	Ana Rita Lourenço M. Guy Roukens Danielle Seinstra Cynthia L. Frederiks Cornelieke E. Pals Stephin J. Vervoort Andreia S. Margarido Jacco van Rheenen Paul J. Coffer
author_sort	Ana Rita Lourenço
title	C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
title_short	C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
title_full	C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
title_fullStr	C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
title_full_unstemmed	C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
title_sort	c/ebpɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b
work_keys_str_mv	AT anaritalourenco cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT mguyroukens cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT danielleseinstra cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT cynthialfrederiks cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT corneliekeepals cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT stephinjvervoort cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT andreiasmargarido cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT jaccovanrheenen cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition AT pauljcoffer cebpɑiscrucialdeterminantofepithelialmaintenancebypreventingepithelialtomesenchymaltransition
_version_	1718380696421007360

C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition

Ejemplares similares