C/EBPɑ is crucial determinant of epithelial maintenance by preventing epithelial-to-mesenchymal transition
In breast cancer TGF-β regulates C/EBPα and can induce epithelial-to-mesenchymal transition (EMT). Here, the authors show that C/EBPα maintains epithelial homeostasis and prevents EMT-mediated tumorigenesis.
Enregistré dans:
Auteurs principaux: | Ana Rita Lourenço, M. Guy Roukens, Danielle Seinstra, Cynthia L. Frederiks, Cornelieke E. Pals, Stephin J. Vervoort, Andreia S. Margarido, Jacco van Rheenen, Paul J. Coffer |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/beb8ddfc0b0b4b249f1fbb7841a7699b |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition.
par: Stephin J Vervoort, et autres
Publié: (2013) -
Mechanical impact of epithelial−mesenchymal transition on epithelial morphogenesis in Drosophila
par: Mélanie Gracia, et autres
Publié: (2019) -
Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells.
par: Atsushi Yasukawa, et autres
Publié: (2013) -
A single-progenitor model as the unifying paradigm of epidermal and esophageal epithelial maintenance in mice
par: Gabriel Piedrafita, et autres
Publié: (2020) -
Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation
par: Ricardo M. Gouveia, et autres
Publié: (2019)