Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis

TNFα can promote three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. Here the authors show that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision.

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Autores principales: Jiefei Geng, Yasushi Ito, Linyu Shi, Palak Amin, Jiachen Chu, Amanda Tomie Ouchida, Adnan Kasim Mookhtiar, Heng Zhao, Daichao Xu, Bing Shan, Ayaz Najafov, Guangping Gao, Shizuo Akira, Junying Yuan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/bebdf94e5c8e42219dc5cf8b4c649af2
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spelling oai:doaj.org-article:bebdf94e5c8e42219dc5cf8b4c649af22021-12-02T17:06:26ZRegulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis10.1038/s41467-017-00406-w2041-1723https://doaj.org/article/bebdf94e5c8e42219dc5cf8b4c649af22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00406-whttps://doaj.org/toc/2041-1723TNFα can promote three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. Here the authors show that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision.Jiefei GengYasushi ItoLinyu ShiPalak AminJiachen ChuAmanda Tomie OuchidaAdnan Kasim MookhtiarHeng ZhaoDaichao XuBing ShanAyaz NajafovGuangping GaoShizuo AkiraJunying YuanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiefei Geng
Yasushi Ito
Linyu Shi
Palak Amin
Jiachen Chu
Amanda Tomie Ouchida
Adnan Kasim Mookhtiar
Heng Zhao
Daichao Xu
Bing Shan
Ayaz Najafov
Guangping Gao
Shizuo Akira
Junying Yuan
Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
description TNFα can promote three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. Here the authors show that TNFα-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating this decision.
format article
author Jiefei Geng
Yasushi Ito
Linyu Shi
Palak Amin
Jiachen Chu
Amanda Tomie Ouchida
Adnan Kasim Mookhtiar
Heng Zhao
Daichao Xu
Bing Shan
Ayaz Najafov
Guangping Gao
Shizuo Akira
Junying Yuan
author_facet Jiefei Geng
Yasushi Ito
Linyu Shi
Palak Amin
Jiachen Chu
Amanda Tomie Ouchida
Adnan Kasim Mookhtiar
Heng Zhao
Daichao Xu
Bing Shan
Ayaz Najafov
Guangping Gao
Shizuo Akira
Junying Yuan
author_sort Jiefei Geng
title Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
title_short Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
title_full Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
title_fullStr Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
title_full_unstemmed Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis
title_sort regulation of ripk1 activation by tak1-mediated phosphorylation dictates apoptosis and necroptosis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/bebdf94e5c8e42219dc5cf8b4c649af2
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