Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles

Yun-jing Hou,1 Xin-xin Yang,1 Rui-qi Liu,2 Di Zhao,1 Chen-xu Guo,1 An-chao Zhu,1 Mei-na Wen,1 Zhao Liu,3 Guo-fan Qu,4 Hong-xue Meng1 1Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Radiation Oncology, Sun Yat-Sen Unive...

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Autores principales:	Hou Y, Yang X, Liu R, Zhao D, Guo C, Zhu A, Wen M, Liu Z, Qu G, Meng H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pathological mechanism nanoparticles photothermal therapy(ptt)，photodynamic therapy(pdt) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bec0c9aaf1f6470ea97e7b366d507383
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spelling	oai:doaj.org-article:bec0c9aaf1f6470ea97e7b366d5073832021-12-02T12:40:56ZPathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles1178-2013https://doaj.org/article/bec0c9aaf1f6470ea97e7b366d5073832020-09-01T00:00:00Zhttps://www.dovepress.com/pathological-mechanism-of-photodynamic-therapy-and-photothermal-therap-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yun-jing Hou,1 Xin-xin Yang,1 Rui-qi Liu,2 Di Zhao,1 Chen-xu Guo,1 An-chao Zhu,1 Mei-na Wen,1 Zhao Liu,3 Guo-fan Qu,4 Hong-xue Meng1 1Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Hospital, Guangzhou, People’s Republic of China; 3Department of Ultrasound, Harbin Medical University, Harbin, People’s Republic of China; 4Department of Orthopedics, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of ChinaCorrespondence: Hong-xue Meng Department of PathologyHarbin Medical University Cancer Hospital, 150 Haping Road, Harbin, People’s Republic of ChinaTel +86-451-85718261Email menghongxue15@163.comAbstract: The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.Keywords: pathological mechanism, nanoparticles, photothermal therapy, PTT, photodynamic therapy, PDTHou YYang XLiu RZhao DGuo CZhu AWen MLiu ZQu GMeng HDove Medical Pressarticlepathological mechanismnanoparticlesphotothermal therapy(ptt)，photodynamic therapy(pdt)Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 6827-6838 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pathological mechanism nanoparticles photothermal therapy(ptt)，photodynamic therapy(pdt) Medicine (General) R5-920
spellingShingle	pathological mechanism nanoparticles photothermal therapy(ptt)，photodynamic therapy(pdt) Medicine (General) R5-920 Hou Y Yang X Liu R Zhao D Guo C Zhu A Wen M Liu Z Qu G Meng H Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
description	Yun-jing Hou,1 Xin-xin Yang,1 Rui-qi Liu,2 Di Zhao,1 Chen-xu Guo,1 An-chao Zhu,1 Mei-na Wen,1 Zhao Liu,3 Guo-fan Qu,4 Hong-xue Meng1 1Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China; 2Department of Radiation Oncology, Sun Yat-Sen University Cancer Hospital, Guangzhou, People’s Republic of China; 3Department of Ultrasound, Harbin Medical University, Harbin, People’s Republic of China; 4Department of Orthopedics, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of ChinaCorrespondence: Hong-xue Meng Department of PathologyHarbin Medical University Cancer Hospital, 150 Haping Road, Harbin, People’s Republic of ChinaTel +86-451-85718261Email menghongxue15@163.comAbstract: The ultimate goal of phototherapy based on nanoparticles, such as photothermal therapy (PTT) which generates heat and photodynamic therapy (PDT) which not only generates reactive oxygen species (ROS) but also induces a variety of anti-tumor immunity, is to kill tumors. In addition, due to strong efficacy in clinical treatment with minimal invasion and negligible side effects, it has received extensive attention and research in recent years. In this paper, the generations of nanomaterials in PTT and PDT are described separately. In clinical application, according to the different combination pathway of nanoparticles, it can be used to treat different diseases such as tumors, melanoma, rheumatoid and so on. In this paper, the mechanism of pathological treatment is described in detail in terms of inducing apoptosis of cancer cells by ROS produced by PDT, immunogenic cell death to provoke the maturation of dendritic cells, which in turn activate production of CD4+ T cells, CD8+T cells and memory T cells, as well as inhibiting heat shock protein (HSPs), STAT3 signal pathway and so on.Keywords: pathological mechanism, nanoparticles, photothermal therapy, PTT, photodynamic therapy, PDT
format	article
author	Hou Y Yang X Liu R Zhao D Guo C Zhu A Wen M Liu Z Qu G Meng H
author_facet	Hou Y Yang X Liu R Zhao D Guo C Zhu A Wen M Liu Z Qu G Meng H
author_sort	Hou Y
title	Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_short	Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_full	Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_fullStr	Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_full_unstemmed	Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles
title_sort	pathological mechanism of photodynamic therapy and photothermal therapy based on nanoparticles
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/bec0c9aaf1f6470ea97e7b366d507383
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Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles

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