Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance
ESR1 mutations occur in endocrine-resistant patients but have not yet been reported in in vitro models of breast cancer. Here, the authors report the discovery of naturally occurring ESR1 Y537Cand ESR1 Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estro...
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Nature Portfolio
2017
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oai:doaj.org-article:bec15e527451427fbda28cf2503940d92021-12-02T15:38:31ZDiscovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance10.1038/s41467-017-01864-y2041-1723https://doaj.org/article/bec15e527451427fbda28cf2503940d92017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01864-yhttps://doaj.org/toc/2041-1723ESR1 mutations occur in endocrine-resistant patients but have not yet been reported in in vitro models of breast cancer. Here, the authors report the discovery of naturally occurring ESR1 Y537Cand ESR1 Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estrogen-deprivation.Lesley-Ann MartinRicardo RibasNikiana SimigdalaEugene SchusterSunil PancholiTencho TenevPascal GellertLaki BuluwelaAlison HarrodAllan ThornhillJoanna Nikitorowicz-BuniakAmandeep BhamraMarc-Olivier TurgeonGeorge PoulogiannisQiong GaoVera MartinsMargaret HillsIsaac Garcia-MurillasCharlotte FribbensNeill PataniZheqi LiMatthew J. SikoraNicholas TurnerWilbert ZwartSteffi OesterreichJason CarrollSimak AliMitch DowsettNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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Science Q Lesley-Ann Martin Ricardo Ribas Nikiana Simigdala Eugene Schuster Sunil Pancholi Tencho Tenev Pascal Gellert Laki Buluwela Alison Harrod Allan Thornhill Joanna Nikitorowicz-Buniak Amandeep Bhamra Marc-Olivier Turgeon George Poulogiannis Qiong Gao Vera Martins Margaret Hills Isaac Garcia-Murillas Charlotte Fribbens Neill Patani Zheqi Li Matthew J. Sikora Nicholas Turner Wilbert Zwart Steffi Oesterreich Jason Carroll Simak Ali Mitch Dowsett Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance |
| description |
ESR1 mutations occur in endocrine-resistant patients but have not yet been reported in in vitro models of breast cancer. Here, the authors report the discovery of naturally occurring ESR1 Y537Cand ESR1 Y537S mutations in two breast cancer cell lines after acquisition of resistance to long-term-estrogen-deprivation. |
| format |
article |
| author |
Lesley-Ann Martin Ricardo Ribas Nikiana Simigdala Eugene Schuster Sunil Pancholi Tencho Tenev Pascal Gellert Laki Buluwela Alison Harrod Allan Thornhill Joanna Nikitorowicz-Buniak Amandeep Bhamra Marc-Olivier Turgeon George Poulogiannis Qiong Gao Vera Martins Margaret Hills Isaac Garcia-Murillas Charlotte Fribbens Neill Patani Zheqi Li Matthew J. Sikora Nicholas Turner Wilbert Zwart Steffi Oesterreich Jason Carroll Simak Ali Mitch Dowsett |
| author_facet |
Lesley-Ann Martin Ricardo Ribas Nikiana Simigdala Eugene Schuster Sunil Pancholi Tencho Tenev Pascal Gellert Laki Buluwela Alison Harrod Allan Thornhill Joanna Nikitorowicz-Buniak Amandeep Bhamra Marc-Olivier Turgeon George Poulogiannis Qiong Gao Vera Martins Margaret Hills Isaac Garcia-Murillas Charlotte Fribbens Neill Patani Zheqi Li Matthew J. Sikora Nicholas Turner Wilbert Zwart Steffi Oesterreich Jason Carroll Simak Ali Mitch Dowsett |
| author_sort |
Lesley-Ann Martin |
| title |
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance |
| title_short |
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance |
| title_full |
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance |
| title_fullStr |
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance |
| title_full_unstemmed |
Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance |
| title_sort |
discovery of naturally occurring esr1 mutations in breast cancer cell lines modelling endocrine resistance |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/bec15e527451427fbda28cf2503940d9 |
| work_keys_str_mv |
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