TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

TERRA RNA has previously been linked to Alternative lengthening of telomeres (ALT). Here the authors developed a tool to rapidly inhibit TERRA transcription from different chromosome ends in an ALT cell line to show that TERRA transcription actively promotes break induced replication (BIR) and desta...

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Autores principales:	Bruno Silva, Rajika Arora, Silvia Bione, Claus M. Azzalin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bec18a68f8c74bdda25115e7a6abfbdc
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spelling	oai:doaj.org-article:bec18a68f8c74bdda25115e7a6abfbdc2021-12-02T16:04:16ZTERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells10.1038/s41467-021-24097-62041-1723https://doaj.org/article/bec18a68f8c74bdda25115e7a6abfbdc2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24097-6https://doaj.org/toc/2041-1723TERRA RNA has previously been linked to Alternative lengthening of telomeres (ALT). Here the authors developed a tool to rapidly inhibit TERRA transcription from different chromosome ends in an ALT cell line to show that TERRA transcription actively promotes break induced replication (BIR) and destabilizes telomere integrity in ALT cells.Bruno SilvaRajika AroraSilvia BioneClaus M. AzzalinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bruno Silva Rajika Arora Silvia Bione Claus M. Azzalin TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
description	TERRA RNA has previously been linked to Alternative lengthening of telomeres (ALT). Here the authors developed a tool to rapidly inhibit TERRA transcription from different chromosome ends in an ALT cell line to show that TERRA transcription actively promotes break induced replication (BIR) and destabilizes telomere integrity in ALT cells.
format	article
author	Bruno Silva Rajika Arora Silvia Bione Claus M. Azzalin
author_facet	Bruno Silva Rajika Arora Silvia Bione Claus M. Azzalin
author_sort	Bruno Silva
title	TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
title_short	TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
title_full	TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
title_fullStr	TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
title_full_unstemmed	TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells
title_sort	terra transcription destabilizes telomere integrity to initiate break-induced replication in human alt cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bec18a68f8c74bdda25115e7a6abfbdc
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TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

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