TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

TERRA RNA has previously been linked to Alternative lengthening of telomeres (ALT). Here the authors developed a tool to rapidly inhibit TERRA transcription from different chromosome ends in an ALT cell line to show that TERRA transcription actively promotes break induced replication (BIR) and desta...

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Autores principales: Bruno Silva, Rajika Arora, Silvia Bione, Claus M. Azzalin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/bec18a68f8c74bdda25115e7a6abfbdc
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