Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study

Anastasios John Kanellopoulos1,2 1Department of Ophthalmology, Laservision Clinical and Research Institute, Athens, Greece; 2Department of Ophthalmology, New York University Medical School, New York, NY, USA Purpose: To investigate ex vivo potentially different corneal biomechanical properties aft...

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Autor principal:	Kanellopoulos AJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	SMILE Femto-second LASIK Myopic LASIK Corneal biomechanics Young’s modulus Corneal stress-strain Shear strength Tensile strength Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/bec2d13d8eb746d49a7c5d3a9e4eeded
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spelling	oai:doaj.org-article:bec2d13d8eb746d49a7c5d3a9e4eeded2021-12-02T05:19:42ZComparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study1177-5483https://doaj.org/article/bec2d13d8eb746d49a7c5d3a9e4eeded2018-01-01T00:00:00Zhttps://www.dovepress.com/comparison-of-corneal-biomechanics-after-myopic-small-incision-lenticu-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Anastasios John Kanellopoulos1,2 1Department of Ophthalmology, Laservision Clinical and Research Institute, Athens, Greece; 2Department of Ophthalmology, New York University Medical School, New York, NY, USA Purpose: To investigate ex vivo potentially different corneal biomechanical properties after small-incision lenticule extraction (SMILE) versus LASIK for myopic correction.Methods: Thirty human donor corneas were subjected to either myopic SMILE or femtosecond laser-assisted LASIK. Donor corneas were assigned to six investigative groups: Group A, –3.00 D (diopters) SMILE; Group B, –8.00 D SMILE; Group C, –3.00 D LASIK; and Group D, –8.00 D LASIK. Additionally, two control groups were formed: Group E, SMILE and Group F, LASIK. All groups consisted of five corneas, randomly allocated. The corneas in the control groups were subjected to the corresponding femtosecond-laser lamellar cuts but not to tissue removal. Evaluation of biomechanical tensile strength was conducted by biaxial force application. Primary outcome measures were stress at 10% and 15% strain, and Young’s modulus at 10% and 15% strain.Results: In SMILE, the average relative difference (Δ) of the four outcome measures was –34.46% for –3.00 D correction versus control Group E and –49.34% for –8.00 D correction versus control Group E. In LASIK, average Δ was –24.88% for –3.00 D correction versus control, and –52.73% for –8.00 D correction versus control. All these differences were statistically significant; SMILE compared to LASIK for the same myopic correction appears to result in more biomechanical reduction for –3.00 D corrections by –26%, while a nonstatistically significant difference was noted in –8.00 D corrections.Conclusion: Both SMILE and LASIK procedures do substantially alter corneal biomechanical properties, and the degree of tensile strength reduction is statistically significantly correlated to the extent of myopic correction. Additionally, SMILE procedure seems to result in more tensile strength reduction in lower myopic corrections compared to LASIK, and similar tensile strength reduction to LASIK in higher myopic corrections when compared to LASIK. Keywords: SMILE, femto-second LASIK, myopic LASIK, corneal biomechanics, Young’s modulus, corneal stress–strain, shear strength, tensile strengthKanellopoulos AJDove Medical PressarticleSMILEFemto-second LASIKMyopic LASIKCorneal biomechanicsYoung’s modulusCorneal stress-strainShear strengthTensile strengthOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 237-245 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	SMILE Femto-second LASIK Myopic LASIK Corneal biomechanics Young’s modulus Corneal stress-strain Shear strength Tensile strength Ophthalmology RE1-994
spellingShingle	SMILE Femto-second LASIK Myopic LASIK Corneal biomechanics Young’s modulus Corneal stress-strain Shear strength Tensile strength Ophthalmology RE1-994 Kanellopoulos AJ Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study
description	Anastasios John Kanellopoulos1,2 1Department of Ophthalmology, Laservision Clinical and Research Institute, Athens, Greece; 2Department of Ophthalmology, New York University Medical School, New York, NY, USA Purpose: To investigate ex vivo potentially different corneal biomechanical properties after small-incision lenticule extraction (SMILE) versus LASIK for myopic correction.Methods: Thirty human donor corneas were subjected to either myopic SMILE or femtosecond laser-assisted LASIK. Donor corneas were assigned to six investigative groups: Group A, –3.00 D (diopters) SMILE; Group B, –8.00 D SMILE; Group C, –3.00 D LASIK; and Group D, –8.00 D LASIK. Additionally, two control groups were formed: Group E, SMILE and Group F, LASIK. All groups consisted of five corneas, randomly allocated. The corneas in the control groups were subjected to the corresponding femtosecond-laser lamellar cuts but not to tissue removal. Evaluation of biomechanical tensile strength was conducted by biaxial force application. Primary outcome measures were stress at 10% and 15% strain, and Young’s modulus at 10% and 15% strain.Results: In SMILE, the average relative difference (Δ) of the four outcome measures was –34.46% for –3.00 D correction versus control Group E and –49.34% for –8.00 D correction versus control Group E. In LASIK, average Δ was –24.88% for –3.00 D correction versus control, and –52.73% for –8.00 D correction versus control. All these differences were statistically significant; SMILE compared to LASIK for the same myopic correction appears to result in more biomechanical reduction for –3.00 D corrections by –26%, while a nonstatistically significant difference was noted in –8.00 D corrections.Conclusion: Both SMILE and LASIK procedures do substantially alter corneal biomechanical properties, and the degree of tensile strength reduction is statistically significantly correlated to the extent of myopic correction. Additionally, SMILE procedure seems to result in more tensile strength reduction in lower myopic corrections compared to LASIK, and similar tensile strength reduction to LASIK in higher myopic corrections when compared to LASIK. Keywords: SMILE, femto-second LASIK, myopic LASIK, corneal biomechanics, Young’s modulus, corneal stress–strain, shear strength, tensile strength
format	article
author	Kanellopoulos AJ
author_facet	Kanellopoulos AJ
author_sort	Kanellopoulos AJ
title	Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study
title_short	Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study
title_full	Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study
title_fullStr	Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study
title_full_unstemmed	Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study
title_sort	comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to lasik: an ex vivo study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/bec2d13d8eb746d49a7c5d3a9e4eeded
work_keys_str_mv	AT kanellopoulosaj comparisonofcornealbiomechanicsaftermyopicsmallincisionlenticuleextractioncomparedtolasikanexvivostudy
_version_	1718400495312175104

Comparison of corneal biomechanics after myopic small-incision lenticule extraction compared to LASIK: an ex vivo study

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