Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation

Abstract Background Timely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests included in the DIC score system. Case presentation Here, we reported a cas...

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Autores principales:	Liqin Ling, Xunbei Huang, Chaonan Liu, Juan Liao, Jing Zhou
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Coagulation Fibrinolysis Hemophagocytic lymphohistiocytosis Disseminated intravascular coagulation Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/bec3ec66bbf04455978508b2faf90e8d
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spelling	oai:doaj.org-article:bec3ec66bbf04455978508b2faf90e8d2021-11-08T10:58:48ZMonitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation10.1186/s12959-021-00338-y1477-9560https://doaj.org/article/bec3ec66bbf04455978508b2faf90e8d2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12959-021-00338-yhttps://doaj.org/toc/1477-9560Abstract Background Timely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests included in the DIC score system. Case presentation Here, we reported a case of lymphoma-associated HLH, in which coagulation-fibrinolysis activation /inhibition markers (TAT, tPAIC, and PIC), prompted timely diagnosis of early stage DIC (initial phase of microvascular thrombosis, yet non-overt), prior to the development of organ failures and/or bleedings. Conclusions This report highlights the importance of the implementation of new biomarkers (such as TAT, tPAIC, and PIC), into the diagnostic work-up for coagulation disorders. These biomarkers are directly suggestive of microthrombus formation, therefore they can be of paramount importance in diagnosing DIC with complicated etiologies, such as hematological diseases-related DIC.Liqin LingXunbei HuangChaonan LiuJuan LiaoJing ZhouBMCarticleCoagulationFibrinolysisHemophagocytic lymphohistiocytosisDisseminated intravascular coagulationDiseases of the blood and blood-forming organsRC633-647.5ENThrombosis Journal, Vol 19, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Coagulation Fibrinolysis Hemophagocytic lymphohistiocytosis Disseminated intravascular coagulation Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Coagulation Fibrinolysis Hemophagocytic lymphohistiocytosis Disseminated intravascular coagulation Diseases of the blood and blood-forming organs RC633-647.5 Liqin Ling Xunbei Huang Chaonan Liu Juan Liao Jing Zhou Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
description	Abstract Background Timely diagnosis of disseminated intravascular coagulation (DIC) in hemophagocytic lymphohistiocytosis (HLH) patients is crucial but challenging, as HLH interferes with the results of the laboratory tests included in the DIC score system. Case presentation Here, we reported a case of lymphoma-associated HLH, in which coagulation-fibrinolysis activation /inhibition markers (TAT, tPAIC, and PIC), prompted timely diagnosis of early stage DIC (initial phase of microvascular thrombosis, yet non-overt), prior to the development of organ failures and/or bleedings. Conclusions This report highlights the importance of the implementation of new biomarkers (such as TAT, tPAIC, and PIC), into the diagnostic work-up for coagulation disorders. These biomarkers are directly suggestive of microthrombus formation, therefore they can be of paramount importance in diagnosing DIC with complicated etiologies, such as hematological diseases-related DIC.
format	article
author	Liqin Ling Xunbei Huang Chaonan Liu Juan Liao Jing Zhou
author_facet	Liqin Ling Xunbei Huang Chaonan Liu Juan Liao Jing Zhou
author_sort	Liqin Ling
title	Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
title_short	Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
title_full	Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
title_fullStr	Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
title_full_unstemmed	Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
title_sort	monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/bec3ec66bbf04455978508b2faf90e8d
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Monitoring coagulation-fibrinolysis activation prompted timely diagnosis of hemophagocytic lymphohistiocytosis-related disseminated intravascular coagulation

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