SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling
The epigenetic mechanisms of melanoma drug resistance are poorly understood. Here, the authors develop a CRISPR-Cas9 screen targeting epigenetic regulators and discover that SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling.
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Nature Portfolio
2018
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oai:doaj.org-article:bec741aeed1b4f7292b8e63eab1bc6992021-12-02T17:31:15ZSIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling10.1038/s41467-018-05966-z2041-1723https://doaj.org/article/bec741aeed1b4f7292b8e63eab1bc6992018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05966-zhttps://doaj.org/toc/2041-1723The epigenetic mechanisms of melanoma drug resistance are poorly understood. Here, the authors develop a CRISPR-Cas9 screen targeting epigenetic regulators and discover that SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling.Thomas StrubFlavia G. GhiraldiniSaul CarcamoMan LiAleksandra WroblewskaRajendra SinghMatthew S. GoldbergDan HassonZichen WangStuart J. GallagherPeter HerseyAvi Ma’ayanGeorgina V. LongRichard A. ScolyerBrian BrownBin ZhengEmily BernsteinNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018) |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Thomas Strub Flavia G. Ghiraldini Saul Carcamo Man Li Aleksandra Wroblewska Rajendra Singh Matthew S. Goldberg Dan Hasson Zichen Wang Stuart J. Gallagher Peter Hersey Avi Ma’ayan Georgina V. Long Richard A. Scolyer Brian Brown Bin Zheng Emily Bernstein SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling |
| description |
The epigenetic mechanisms of melanoma drug resistance are poorly understood. Here, the authors develop a CRISPR-Cas9 screen targeting epigenetic regulators and discover that SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling. |
| format |
article |
| author |
Thomas Strub Flavia G. Ghiraldini Saul Carcamo Man Li Aleksandra Wroblewska Rajendra Singh Matthew S. Goldberg Dan Hasson Zichen Wang Stuart J. Gallagher Peter Hersey Avi Ma’ayan Georgina V. Long Richard A. Scolyer Brian Brown Bin Zheng Emily Bernstein |
| author_facet |
Thomas Strub Flavia G. Ghiraldini Saul Carcamo Man Li Aleksandra Wroblewska Rajendra Singh Matthew S. Goldberg Dan Hasson Zichen Wang Stuart J. Gallagher Peter Hersey Avi Ma’ayan Georgina V. Long Richard A. Scolyer Brian Brown Bin Zheng Emily Bernstein |
| author_sort |
Thomas Strub |
| title |
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling |
| title_short |
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling |
| title_full |
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling |
| title_fullStr |
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling |
| title_full_unstemmed |
SIRT6 haploinsufficiency induces BRAFV600E melanoma cell resistance to MAPK inhibitors via IGF signalling |
| title_sort |
sirt6 haploinsufficiency induces brafv600e melanoma cell resistance to mapk inhibitors via igf signalling |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/bec741aeed1b4f7292b8e63eab1bc699 |
| work_keys_str_mv |
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