An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure

Abstract This study sought to evaluate the association between newly-developed significant hypercholesterolemia within one year following living donor liver transplantation (LDLT) and long term outcomes in light of cardiovascular events and graft failure. From October 2003 to July 2017, 877 LDLT rec...

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Autores principales:	Jungchan Park, Seung-Hwa Lee, Sangbin Han, Ah Ran Oh, Suk-Koo Lee, Gyu-Seong Choi, Myung Soo Park, Keumhee Carriere, Joonghyun Ahn, Gaab Soo Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bec8c059c9ad4eafb9110f59d0e5f16b
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spelling	oai:doaj.org-article:bec8c059c9ad4eafb9110f59d0e5f16b2021-12-02T14:01:35ZAn observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure10.1038/s41598-020-79673-52045-2322https://doaj.org/article/bec8c059c9ad4eafb9110f59d0e5f16b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79673-5https://doaj.org/toc/2045-2322Abstract This study sought to evaluate the association between newly-developed significant hypercholesterolemia within one year following living donor liver transplantation (LDLT) and long term outcomes in light of cardiovascular events and graft failure. From October 2003 to July 2017, 877 LDLT recipients were stratified according to development of significant hypercholesterolemia within one year following LDLT. The primary outcome was occurrence of a major adverse cardiac event (MACE), defined as a composite of cardiac death, myocardial infarction, and coronary revascularization after LDLT. The incidence of graft failure, defined as all-cause death or retransplantation, was also compared. A total of 113 (12.9%) recipients developed significant hypercholesterolemia within one year. The differences in incidences of cardiac related events and graft related events began emerging significantly higher in the hypercholesterolemia group after 24 months and 60 months since the LDLT, respectively. After adjustment using the inverse probability of weighting, the hazard ratio (HR) for MACE was 2.77 (95% confidence interval (CI) 1.16–6.61; p = 0.02), while that for graft failure was 3.76 (95% CI 1.97–7.17, p < 0.001). A significant hypercholesterolemia after LDLT may be associated with cardiac and graft-related outcome; therefore, a further study and close monitoring of cholesterol level after LDLT is needed.Jungchan ParkSeung-Hwa LeeSangbin HanAh Ran OhSuk-Koo LeeGyu-Seong ChoiMyung Soo ParkKeumhee CarriereJoonghyun AhnGaab Soo KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jungchan Park Seung-Hwa Lee Sangbin Han Ah Ran Oh Suk-Koo Lee Gyu-Seong Choi Myung Soo Park Keumhee Carriere Joonghyun Ahn Gaab Soo Kim An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
description	Abstract This study sought to evaluate the association between newly-developed significant hypercholesterolemia within one year following living donor liver transplantation (LDLT) and long term outcomes in light of cardiovascular events and graft failure. From October 2003 to July 2017, 877 LDLT recipients were stratified according to development of significant hypercholesterolemia within one year following LDLT. The primary outcome was occurrence of a major adverse cardiac event (MACE), defined as a composite of cardiac death, myocardial infarction, and coronary revascularization after LDLT. The incidence of graft failure, defined as all-cause death or retransplantation, was also compared. A total of 113 (12.9%) recipients developed significant hypercholesterolemia within one year. The differences in incidences of cardiac related events and graft related events began emerging significantly higher in the hypercholesterolemia group after 24 months and 60 months since the LDLT, respectively. After adjustment using the inverse probability of weighting, the hazard ratio (HR) for MACE was 2.77 (95% confidence interval (CI) 1.16–6.61; p = 0.02), while that for graft failure was 3.76 (95% CI 1.97–7.17, p < 0.001). A significant hypercholesterolemia after LDLT may be associated with cardiac and graft-related outcome; therefore, a further study and close monitoring of cholesterol level after LDLT is needed.
format	article
author	Jungchan Park Seung-Hwa Lee Sangbin Han Ah Ran Oh Suk-Koo Lee Gyu-Seong Choi Myung Soo Park Keumhee Carriere Joonghyun Ahn Gaab Soo Kim
author_facet	Jungchan Park Seung-Hwa Lee Sangbin Han Ah Ran Oh Suk-Koo Lee Gyu-Seong Choi Myung Soo Park Keumhee Carriere Joonghyun Ahn Gaab Soo Kim
author_sort	Jungchan Park
title	An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
title_short	An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
title_full	An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
title_fullStr	An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
title_full_unstemmed	An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
title_sort	observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bec8c059c9ad4eafb9110f59d0e5f16b
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An observational study on the effect of hypercholesterolemia developed after living donor liver transplantation on cardiac event and graft failure

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