Myositis Specific Autoantibodies: A Clinical Perspective

Fahidah M Alenzi Department of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaCorrespondence: Fahidah M AlenziDepartment of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaEmail fmalenzi@...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Alenzi FM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	dermatomyositis specific autoantibodies clinical presentation Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/becc9cc2a05c4cb4b3a023ba9cf656ce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:becc9cc2a05c4cb4b3a023ba9cf656ce
record_format	dspace
spelling	oai:doaj.org-article:becc9cc2a05c4cb4b3a023ba9cf656ce2021-12-02T08:54:27ZMyositis Specific Autoantibodies: A Clinical Perspective1179-156Xhttps://doaj.org/article/becc9cc2a05c4cb4b3a023ba9cf656ce2020-01-01T00:00:00Zhttps://www.dovepress.com/myositis-specific-autoantibodies-a-clinical-perspective-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XFahidah M Alenzi Department of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaCorrespondence: Fahidah M AlenziDepartment of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaEmail fmalenzi@pnu.edu.saAbstract: Dermatomyositis (DM) is an idiopathic inflammatory condition characterized by myositis and variable skin manifestation. The existence of myositis specific autoantibodies usually manifests with varying degrees of skin or muscle inflammations. The condition has a well-established association with most clinical phenotypes, and these autoantibodies are useful in informing the diagnosis, management and prognosis of the disease. DM-specific autoantibodies include anti-MDA5, anti-NXP2, anti-SAE, anti-Mi-2, anti-ARS, anti-TIF1-gamma. Anti-Mi-2 antibodies are widely associated with DM cases that exhibit mainly cutaneous symptoms, such as cuticular overgrowths, Gottron’s papules while being less susceptible to complications like interstitial lung disease or malignancy. The most distinct clinical features of patients with anti-SAE antibodies are their high prevalence of dysphagia and cutaneous manifestations that antecede the development of myopathies. In addition, DM patients with positive anti-PL-7 antibodies tend to have milder myositis characterized by low levels of creatine kinase as compared to patients with positive anti-Jo-1 antibodies. The anti-NXP2 antibodies are associated with transcriptional regulation and production of various proteins targeted by other DM antibodies, while anti- TIF1-γ. facilitates the transcription of deoxyribonucleic acids and regulates the growth and subsequent differentiation of body cells by controlling the signaling of TGF-β. The present review targets DM specific autoantibodies, considering their association, significance, and clinical presentationKeywords: dermatomyositis, specific autoantibodies, clinical presentationAlenzi FMDove Medical Pressarticledermatomyositisspecific autoantibodiesclinical presentationDiseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 9-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermatomyositis specific autoantibodies clinical presentation Diseases of the musculoskeletal system RC925-935
spellingShingle	dermatomyositis specific autoantibodies clinical presentation Diseases of the musculoskeletal system RC925-935 Alenzi FM Myositis Specific Autoantibodies: A Clinical Perspective
description	Fahidah M Alenzi Department of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaCorrespondence: Fahidah M AlenziDepartment of Clinical Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaEmail fmalenzi@pnu.edu.saAbstract: Dermatomyositis (DM) is an idiopathic inflammatory condition characterized by myositis and variable skin manifestation. The existence of myositis specific autoantibodies usually manifests with varying degrees of skin or muscle inflammations. The condition has a well-established association with most clinical phenotypes, and these autoantibodies are useful in informing the diagnosis, management and prognosis of the disease. DM-specific autoantibodies include anti-MDA5, anti-NXP2, anti-SAE, anti-Mi-2, anti-ARS, anti-TIF1-gamma. Anti-Mi-2 antibodies are widely associated with DM cases that exhibit mainly cutaneous symptoms, such as cuticular overgrowths, Gottron’s papules while being less susceptible to complications like interstitial lung disease or malignancy. The most distinct clinical features of patients with anti-SAE antibodies are their high prevalence of dysphagia and cutaneous manifestations that antecede the development of myopathies. In addition, DM patients with positive anti-PL-7 antibodies tend to have milder myositis characterized by low levels of creatine kinase as compared to patients with positive anti-Jo-1 antibodies. The anti-NXP2 antibodies are associated with transcriptional regulation and production of various proteins targeted by other DM antibodies, while anti- TIF1-γ. facilitates the transcription of deoxyribonucleic acids and regulates the growth and subsequent differentiation of body cells by controlling the signaling of TGF-β. The present review targets DM specific autoantibodies, considering their association, significance, and clinical presentationKeywords: dermatomyositis, specific autoantibodies, clinical presentation
format	article
author	Alenzi FM
author_facet	Alenzi FM
author_sort	Alenzi FM
title	Myositis Specific Autoantibodies: A Clinical Perspective
title_short	Myositis Specific Autoantibodies: A Clinical Perspective
title_full	Myositis Specific Autoantibodies: A Clinical Perspective
title_fullStr	Myositis Specific Autoantibodies: A Clinical Perspective
title_full_unstemmed	Myositis Specific Autoantibodies: A Clinical Perspective
title_sort	myositis specific autoantibodies: a clinical perspective
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/becc9cc2a05c4cb4b3a023ba9cf656ce
work_keys_str_mv	AT alenzifm myositisspecificautoantibodiesaclinicalperspective
_version_	1718398328347033600

Myositis Specific Autoantibodies: A Clinical Perspective

Ejemplares similares