Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans

Farzaneh A Sorond1,2, Lewis A Lipsitz2,4, Norman K Hollenberg3,5, Naomi DL Fisher31Department of Neurology, Stroke Division; 2Institute for Aging Research, Hebrew SeniorLife, Boston, MA; 3Department of Medicine, Endocrine-Hypertension Division; 4Department of Medicine, Gerontology, Beth Israel Deaco...

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Autores principales:	Farzaneh A Sorond, Lewis A Lipsitz, Norman K Hollenberg, Naomi DL Fisher
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/becf754b10294a108dc326bd7c0d5219
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spelling	oai:doaj.org-article:becf754b10294a108dc326bd7c0d52192021-12-02T02:37:56ZCerebral blood flow response to flavanol-rich cocoa in healthy elderly humans1176-63281178-2021https://doaj.org/article/becf754b10294a108dc326bd7c0d52192008-04-01T00:00:00Zhttp://www.dovepress.com/cerebral-blood-flow-response-to-flavanol-rich-cocoa-in-healthy-elderly-a1026https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Farzaneh A Sorond1,2, Lewis A Lipsitz2,4, Norman K Hollenberg3,5, Naomi DL Fisher31Department of Neurology, Stroke Division; 2Institute for Aging Research, Hebrew SeniorLife, Boston, MA; 3Department of Medicine, Endocrine-Hypertension Division; 4Department of Medicine, Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 5Department of Radiology, Brigham and Women&rsquo;s Hospital, Boston, MABackground and Purpose: Cerebral ischemia is a common, morbid condition accompanied by cognitive decline. Recent reports on the vascular health benefits of flavanol-containing foods signify a promising approach to the treatment of cerebral ischemia. Our study was designed to investigate the effects of flavanol-rich cocoa (FRC) consumption on cerebral blood flow in older healthy volunteers.Methods: We used transcranial Doppler (TCD) ultrasound to measure mean blood flow velocity (MFV) in the middle cerebral artery (MCA) in thirty-four healthy elderly volunteers (72 &plusmn; 6 years) in response to the regular intake of FRC or flavanol-poor cocoa (FPC).Results: In response to two weeks of FRC intake, MFV increased by 8% &plusmn; 4% at one week (p = 0.01) and 10% &plusmn; 4% (p = 0.04) at two weeks. In response to one week of cocoa, significantly more subjects in the FRC as compared with the FPC group had an increase in their MFV (p &lt; 0.05).Conclusions: In summary, we show that dietary intake of FRC is associated with a significant increase in cerebral blood flow velocity in the MCA as measured by TCD. Our data suggest a promising role for regular cocoa flavanol&rsquo;s consumption in the treatment of cerebrovascular ischemic syndromes, including dementias and stroke.Keywords: cerebral blood flow, flavanol, cocoa, transcranial Doppler ultrasound Farzaneh A SorondLewis A LipsitzNorman K HollenbergNaomi DL FisherDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 2, Pp 433-440 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Farzaneh A Sorond Lewis A Lipsitz Norman K Hollenberg Naomi DL Fisher Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
description	Farzaneh A Sorond1,2, Lewis A Lipsitz2,4, Norman K Hollenberg3,5, Naomi DL Fisher31Department of Neurology, Stroke Division; 2Institute for Aging Research, Hebrew SeniorLife, Boston, MA; 3Department of Medicine, Endocrine-Hypertension Division; 4Department of Medicine, Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 5Department of Radiology, Brigham and Women&rsquo;s Hospital, Boston, MABackground and Purpose: Cerebral ischemia is a common, morbid condition accompanied by cognitive decline. Recent reports on the vascular health benefits of flavanol-containing foods signify a promising approach to the treatment of cerebral ischemia. Our study was designed to investigate the effects of flavanol-rich cocoa (FRC) consumption on cerebral blood flow in older healthy volunteers.Methods: We used transcranial Doppler (TCD) ultrasound to measure mean blood flow velocity (MFV) in the middle cerebral artery (MCA) in thirty-four healthy elderly volunteers (72 &plusmn; 6 years) in response to the regular intake of FRC or flavanol-poor cocoa (FPC).Results: In response to two weeks of FRC intake, MFV increased by 8% &plusmn; 4% at one week (p = 0.01) and 10% &plusmn; 4% (p = 0.04) at two weeks. In response to one week of cocoa, significantly more subjects in the FRC as compared with the FPC group had an increase in their MFV (p &lt; 0.05).Conclusions: In summary, we show that dietary intake of FRC is associated with a significant increase in cerebral blood flow velocity in the MCA as measured by TCD. Our data suggest a promising role for regular cocoa flavanol&rsquo;s consumption in the treatment of cerebrovascular ischemic syndromes, including dementias and stroke.Keywords: cerebral blood flow, flavanol, cocoa, transcranial Doppler ultrasound
format	article
author	Farzaneh A Sorond Lewis A Lipsitz Norman K Hollenberg Naomi DL Fisher
author_facet	Farzaneh A Sorond Lewis A Lipsitz Norman K Hollenberg Naomi DL Fisher
author_sort	Farzaneh A Sorond
title	Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
title_short	Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
title_full	Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
title_fullStr	Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
title_full_unstemmed	Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
title_sort	cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/becf754b10294a108dc326bd7c0d5219
work_keys_str_mv	AT farzanehasorond cerebralbloodflowresponsetoflavanolrichcocoainhealthyelderlyhumans AT lewisalipsitz cerebralbloodflowresponsetoflavanolrichcocoainhealthyelderlyhumans AT normankhollenberg cerebralbloodflowresponsetoflavanolrichcocoainhealthyelderlyhumans AT naomidlfisher cerebralbloodflowresponsetoflavanolrichcocoainhealthyelderlyhumans
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Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans

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