Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite

Tissue fibrosis causes debilitating human diseases such as liver cirrhosis, heart failure, chronic kidney disease and pulmonary insufficiency. It is a dynamic process orchestrated by specific subsets of monocyte-macrophages, fibroblasts, pericytes and hepatic stellate cells. Fibrosis is linked to ti...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Kenneth K Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fibrosis 5-methoxytryptophan liver cirrhosis heart failure fibroblasts myofibroblasts Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/bed014173b834a0b8b8103a795a28c8a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bed014173b834a0b8b8103a795a28c8a
record_format	dspace
spelling	oai:doaj.org-article:bed014173b834a0b8b8103a795a28c8a2021-11-11T08:56:16ZControl of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite1663-981210.3389/fphar.2021.759199https://doaj.org/article/bed014173b834a0b8b8103a795a28c8a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.759199/fullhttps://doaj.org/toc/1663-9812Tissue fibrosis causes debilitating human diseases such as liver cirrhosis, heart failure, chronic kidney disease and pulmonary insufficiency. It is a dynamic process orchestrated by specific subsets of monocyte-macrophages, fibroblasts, pericytes and hepatic stellate cells. Fibrosis is linked to tissue inflammation. Pro-inflammatory macrophages promote fibrosis by driving myofibroblast differentiation and macrophage myofibroblast transition. Myofibroblasts express α-smooth muscle cell actin (α-SMA) and secrete extracellular matrix (ECM) proteins notably collagen I and III. Deposition of ECM proteins at injury sites and interstitial tissues distorts normal structure and impairs vital functions. Despite advances in the mechanisms of fibrosis at cellular, molecular and genetic levels, prevention and treatment of fibrotic diseases remain poorly developed. Recent reports suggest that 5-methoxytryptophan (5-MTP) is effective in attenuating injury-induced liver, kidney, cardiac and pulmonary fibrosis. It inhibits macrophage activation and blocks fibroblast differentiation to myofibroblasts. Furthermore, it inhibits hepatic stellate cell differentiation into myofibroblasts. As 5-MTP is an endogenous molecule derived from tryptophan catabolism via tryptophan hydroxylase pathway, it is well-suited as a lead compound for developing new anti-fibrotic drugs. This article provides an overview of 5-MTP synthesis, and a critical review of its anti-fibrotic activities. Its mechanisms of actions and potential therapeutic value will be discussed.Kenneth K WuKenneth K WuFrontiers Media S.A.articlefibrosis5-methoxytryptophanliver cirrhosisheart failurefibroblastsmyofibroblastsTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibrosis 5-methoxytryptophan liver cirrhosis heart failure fibroblasts myofibroblasts Therapeutics. Pharmacology RM1-950
spellingShingle	fibrosis 5-methoxytryptophan liver cirrhosis heart failure fibroblasts myofibroblasts Therapeutics. Pharmacology RM1-950 Kenneth K Wu Kenneth K Wu Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite
description	Tissue fibrosis causes debilitating human diseases such as liver cirrhosis, heart failure, chronic kidney disease and pulmonary insufficiency. It is a dynamic process orchestrated by specific subsets of monocyte-macrophages, fibroblasts, pericytes and hepatic stellate cells. Fibrosis is linked to tissue inflammation. Pro-inflammatory macrophages promote fibrosis by driving myofibroblast differentiation and macrophage myofibroblast transition. Myofibroblasts express α-smooth muscle cell actin (α-SMA) and secrete extracellular matrix (ECM) proteins notably collagen I and III. Deposition of ECM proteins at injury sites and interstitial tissues distorts normal structure and impairs vital functions. Despite advances in the mechanisms of fibrosis at cellular, molecular and genetic levels, prevention and treatment of fibrotic diseases remain poorly developed. Recent reports suggest that 5-methoxytryptophan (5-MTP) is effective in attenuating injury-induced liver, kidney, cardiac and pulmonary fibrosis. It inhibits macrophage activation and blocks fibroblast differentiation to myofibroblasts. Furthermore, it inhibits hepatic stellate cell differentiation into myofibroblasts. As 5-MTP is an endogenous molecule derived from tryptophan catabolism via tryptophan hydroxylase pathway, it is well-suited as a lead compound for developing new anti-fibrotic drugs. This article provides an overview of 5-MTP synthesis, and a critical review of its anti-fibrotic activities. Its mechanisms of actions and potential therapeutic value will be discussed.
format	article
author	Kenneth K Wu Kenneth K Wu
author_facet	Kenneth K Wu Kenneth K Wu
author_sort	Kenneth K Wu
title	Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite
title_short	Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite
title_full	Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite
title_fullStr	Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite
title_full_unstemmed	Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite
title_sort	control of tissue fibrosis by 5-methoxytryptophan, an innate anti-inflammatory metabolite
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/bed014173b834a0b8b8103a795a28c8a
work_keys_str_mv	AT kennethkwu controloftissuefibrosisby5methoxytryptophananinnateantiinflammatorymetabolite AT kennethkwu controloftissuefibrosisby5methoxytryptophananinnateantiinflammatorymetabolite
_version_	1718439347721601024

Control of Tissue Fibrosis by 5-Methoxytryptophan, an Innate Anti-Inflammatory Metabolite

Ejemplares similares