Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity

Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity

Aldehyde-alcohol dehydrogenase (AdhE) converts acetyl-CoA to ethanol and plays an important role in bacterial fermentation. Here the authors present the 3.5 Å cryo-EM structure of full-length E. coli AdhE, which reveals a right-handed helical spirosome structure and they show that the helical struct...

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Autores principales: Gijeong Kim, Liyana Azmi, Seongmin Jang, Taeyang Jung, Hans Hebert, Andrew J. Roe, Olwyn Byron, Ji-Joon Song
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/bed36c0da3d94639a3797af3c65586f6
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spelling oai:doaj.org-article:bed36c0da3d94639a3797af3c65586f62021-12-02T17:33:11ZAldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity10.1038/s41467-019-12427-82041-1723https://doaj.org/article/bed36c0da3d94639a3797af3c65586f62019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12427-8https://doaj.org/toc/2041-1723Aldehyde-alcohol dehydrogenase (AdhE) converts acetyl-CoA to ethanol and plays an important role in bacterial fermentation. Here the authors present the 3.5 Å cryo-EM structure of full-length E. coli AdhE, which reveals a right-handed helical spirosome structure and they show that the helical structure is required for AdhE activity.Gijeong KimLiyana AzmiSeongmin JangTaeyang JungHans HebertAndrew J. RoeOlwyn ByronJi-Joon SongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Gijeong Kim
Liyana Azmi
Seongmin Jang
Taeyang Jung
Hans Hebert
Andrew J. Roe
Olwyn Byron
Ji-Joon Song
Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
description Aldehyde-alcohol dehydrogenase (AdhE) converts acetyl-CoA to ethanol and plays an important role in bacterial fermentation. Here the authors present the 3.5 Å cryo-EM structure of full-length E. coli AdhE, which reveals a right-handed helical spirosome structure and they show that the helical structure is required for AdhE activity.
format article
author Gijeong Kim
Liyana Azmi
Seongmin Jang
Taeyang Jung
Hans Hebert
Andrew J. Roe
Olwyn Byron
Ji-Joon Song
author_facet Gijeong Kim
Liyana Azmi
Seongmin Jang
Taeyang Jung
Hans Hebert
Andrew J. Roe
Olwyn Byron
Ji-Joon Song
author_sort Gijeong Kim
title Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
title_short Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
title_full Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
title_fullStr Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
title_full_unstemmed Aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
title_sort aldehyde-alcohol dehydrogenase forms a high-order spirosome architecture critical for its activity
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/bed36c0da3d94639a3797af3c65586f6
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AT liyanaazmi aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
AT seongminjang aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
AT taeyangjung aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
AT hanshebert aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
AT andrewjroe aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
AT olwynbyron aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
AT jijoonsong aldehydealcoholdehydrogenaseformsahighorderspirosomearchitecturecriticalforitsactivity
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