Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging

How cellular noise impacts metabolic trade-offs remains unknown. Here, the authors use a quantitative single-cell mass imaging strategy to reveal that cellular noise impacts cellular biomass and triacylglycerol accumulation, as well as protein and fatty-acid recycling under starvation, differently.

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Autores principales:	A. E. Vasdekis, H. Alanazi, A. M. Silverman, C. J. Williams, A. J. Canul, J. B. Cliff, A. C. Dohnalkova, G. Stephanopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bed58e703c6548dc9176a2d49e6a0ce3
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spelling	oai:doaj.org-article:bed58e703c6548dc9176a2d49e6a0ce32021-12-02T15:36:23ZEliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging10.1038/s41467-019-08717-w2041-1723https://doaj.org/article/bed58e703c6548dc9176a2d49e6a0ce32019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08717-whttps://doaj.org/toc/2041-1723How cellular noise impacts metabolic trade-offs remains unknown. Here, the authors use a quantitative single-cell mass imaging strategy to reveal that cellular noise impacts cellular biomass and triacylglycerol accumulation, as well as protein and fatty-acid recycling under starvation, differently.A. E. VasdekisH. AlanaziA. M. SilvermanC. J. WilliamsA. J. CanulJ. B. CliffA. C. DohnalkovaG. StephanopoulosNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. E. Vasdekis H. Alanazi A. M. Silverman C. J. Williams A. J. Canul J. B. Cliff A. C. Dohnalkova G. Stephanopoulos Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
description	How cellular noise impacts metabolic trade-offs remains unknown. Here, the authors use a quantitative single-cell mass imaging strategy to reveal that cellular noise impacts cellular biomass and triacylglycerol accumulation, as well as protein and fatty-acid recycling under starvation, differently.
format	article
author	A. E. Vasdekis H. Alanazi A. M. Silverman C. J. Williams A. J. Canul J. B. Cliff A. C. Dohnalkova G. Stephanopoulos
author_facet	A. E. Vasdekis H. Alanazi A. M. Silverman C. J. Williams A. J. Canul J. B. Cliff A. C. Dohnalkova G. Stephanopoulos
author_sort	A. E. Vasdekis
title	Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
title_short	Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
title_full	Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
title_fullStr	Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
title_full_unstemmed	Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
title_sort	eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/bed58e703c6548dc9176a2d49e6a0ce3
work_keys_str_mv	AT aevasdekis elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT halanazi elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT amsilverman elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT cjwilliams elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT ajcanul elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT jbcliff elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT acdohnalkova elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging AT gstephanopoulos elicitingtheimpactsofcellularnoiseonmetabolictradeoffsbyquantitativemassimaging
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Eliciting the impacts of cellular noise on metabolic trade-offs by quantitative mass imaging

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