The Entorhinal Cortex and Adult Neurogenesis in Major Depression

Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in...

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Autores principales:	Il Bin Kim, Seon-Cheol Park
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	depression entorhinal cortex hippocampus cognition emotion neural circuitry Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/bed87b9b8a5e456a8e5e8a0b390ebeb9
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spelling	oai:doaj.org-article:bed87b9b8a5e456a8e5e8a0b390ebeb92021-11-11T17:10:56ZThe Entorhinal Cortex and Adult Neurogenesis in Major Depression10.3390/ijms2221117251422-00671661-6596https://doaj.org/article/bed87b9b8a5e456a8e5e8a0b390ebeb92021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11725https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. In particular, the entorhinal cortex is known to have a regulatory effect on the neural circuitry related to hippocampal function and adult neurogenesis. However, a comprehensive understanding of how disruption of the neural circuitry can lead to neurogenesis impairments in depression remains unclear with respect to the regulatory role of the entorhinal cortex. This review highlights recent findings suggesting neural circuitry-regulated neurogenesis, with a focus on the potential role of the entorhinal cortex in hippocampal neurogenesis in depression-related cognitive and emotional phenotypes. Taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression.Il Bin KimSeon-Cheol ParkMDPI AGarticledepressionentorhinal cortexhippocampuscognitionemotionneural circuitryBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11725, p 11725 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression entorhinal cortex hippocampus cognition emotion neural circuitry Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	depression entorhinal cortex hippocampus cognition emotion neural circuitry Biology (General) QH301-705.5 Chemistry QD1-999 Il Bin Kim Seon-Cheol Park The Entorhinal Cortex and Adult Neurogenesis in Major Depression
description	Depression is characterized by impairments in adult neurogenesis. Reduced hippocampal function, which is suggestive of neurogenesis impairments, is associated with depression-related phenotypes. As adult neurogenesis operates in an activity-dependent manner, disruption of hippocampal neurogenesis in depression may be a consequence of neural circuitry impairments. In particular, the entorhinal cortex is known to have a regulatory effect on the neural circuitry related to hippocampal function and adult neurogenesis. However, a comprehensive understanding of how disruption of the neural circuitry can lead to neurogenesis impairments in depression remains unclear with respect to the regulatory role of the entorhinal cortex. This review highlights recent findings suggesting neural circuitry-regulated neurogenesis, with a focus on the potential role of the entorhinal cortex in hippocampal neurogenesis in depression-related cognitive and emotional phenotypes. Taken together, these findings may provide a better understanding of the entorhinal cortex-regulated hippocampal neurogenesis model of depression.
format	article
author	Il Bin Kim Seon-Cheol Park
author_facet	Il Bin Kim Seon-Cheol Park
author_sort	Il Bin Kim
title	The Entorhinal Cortex and Adult Neurogenesis in Major Depression
title_short	The Entorhinal Cortex and Adult Neurogenesis in Major Depression
title_full	The Entorhinal Cortex and Adult Neurogenesis in Major Depression
title_fullStr	The Entorhinal Cortex and Adult Neurogenesis in Major Depression
title_full_unstemmed	The Entorhinal Cortex and Adult Neurogenesis in Major Depression
title_sort	entorhinal cortex and adult neurogenesis in major depression
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bed87b9b8a5e456a8e5e8a0b390ebeb9
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The Entorhinal Cortex and Adult Neurogenesis in Major Depression

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