The Plasmodium export element revisited.

We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family...

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Autores principales:	Jan Alexander Hiss, Jude Marek Przyborski, Florian Schwarte, Klaus Lingelbach, Gisbert Schneider
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bed9213ee1f545e7a89c49ffd6b66781
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spelling	oai:doaj.org-article:bed9213ee1f545e7a89c49ffd6b667812021-11-25T06:13:28ZThe Plasmodium export element revisited.1932-620310.1371/journal.pone.0001560https://doaj.org/article/bed9213ee1f545e7a89c49ffd6b667812008-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18253504/?tool=EBIhttps://doaj.org/toc/1932-6203We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.Jan Alexander HissJude Marek PrzyborskiFlorian SchwarteKlaus LingelbachGisbert SchneiderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 2, p e1560 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jan Alexander Hiss Jude Marek Przyborski Florian Schwarte Klaus Lingelbach Gisbert Schneider The Plasmodium export element revisited.
description	We performed a bioinformatical analysis of protein export elements (PEXEL) in the putative proteome of the malaria parasite Plasmodium falciparum. A protein family-specific conservation of physicochemical residue profiles was found for PEXEL-flanking sequence regions. We demonstrate that the family members can be clustered based on the flanking regions only and display characteristic hydrophobicity patterns. This raises the possibility that the flanking regions may contain additional information for a family-specific role of PEXEL. We further show that signal peptide cleavage results in a positional alignment of PEXEL from both proteins with, and without, a signal peptide.
format	article
author	Jan Alexander Hiss Jude Marek Przyborski Florian Schwarte Klaus Lingelbach Gisbert Schneider
author_facet	Jan Alexander Hiss Jude Marek Przyborski Florian Schwarte Klaus Lingelbach Gisbert Schneider
author_sort	Jan Alexander Hiss
title	The Plasmodium export element revisited.
title_short	The Plasmodium export element revisited.
title_full	The Plasmodium export element revisited.
title_fullStr	The Plasmodium export element revisited.
title_full_unstemmed	The Plasmodium export element revisited.
title_sort	plasmodium export element revisited.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/bed9213ee1f545e7a89c49ffd6b66781
work_keys_str_mv	AT janalexanderhiss theplasmodiumexportelementrevisited AT judemarekprzyborski theplasmodiumexportelementrevisited AT florianschwarte theplasmodiumexportelementrevisited AT klauslingelbach theplasmodiumexportelementrevisited AT gisbertschneider theplasmodiumexportelementrevisited AT janalexanderhiss plasmodiumexportelementrevisited AT judemarekprzyborski plasmodiumexportelementrevisited AT florianschwarte plasmodiumexportelementrevisited AT klauslingelbach plasmodiumexportelementrevisited AT gisbertschneider plasmodiumexportelementrevisited
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The Plasmodium export element revisited.

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