A Solution to Antifolate Resistance in Group B <italic toggle="yes">Streptococcus</italic>: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

A Solution to Antifolate Resistance in Group B <italic toggle="yes">Streptococcus</italic>: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim

ABSTRACT Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B Streptococcus (GBS) to trimethoprim (TMP), an antibio...

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Autores principales: Schuyler A. Chambers, Rebecca E. Moore, Kelly M. Craft, Harrison C. Thomas, Rishub Das, Shannon D. Manning, Simona G. Codreanu, Stacy D. Sherrod, David M. Aronoff, John A. McLean, Jennifer A. Gaddy, Steven D. Townsend
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
group B Streptococcus
human milk oligosaccharides
resistance
adjuvants
antifolate drugs
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/bed98e0db5e049edbda650b23600e004
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