LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation

De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with diverge...

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Autores principales: Julie Brind’Amour, Hisato Kobayashi, Julien Richard Albert, Kenjiro Shirane, Akihiko Sakashita, Asuka Kamio, Aaron Bogutz, Tasuku Koike, Mohammad M. Karimi, Louis Lefebvre, Tomohiro Kono, Matthew C. Lorincz
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f09
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spelling oai:doaj.org-article:bee0bd7cd38c4fa6acd4a2ae886f0f092021-12-02T16:56:55ZLTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation10.1038/s41467-018-05841-x2041-1723https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f092018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05841-xhttps://doaj.org/toc/2041-1723De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.Julie Brind’AmourHisato KobayashiJulien Richard AlbertKenjiro ShiraneAkihiko SakashitaAsuka KamioAaron BogutzTasuku KoikeMohammad M. KarimiLouis LefebvreTomohiro KonoMatthew C. LorinczNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julie Brind’Amour
Hisato Kobayashi
Julien Richard Albert
Kenjiro Shirane
Akihiko Sakashita
Asuka Kamio
Aaron Bogutz
Tasuku Koike
Mohammad M. Karimi
Louis Lefebvre
Tomohiro Kono
Matthew C. Lorincz
LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
description De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.
format article
author Julie Brind’Amour
Hisato Kobayashi
Julien Richard Albert
Kenjiro Shirane
Akihiko Sakashita
Asuka Kamio
Aaron Bogutz
Tasuku Koike
Mohammad M. Karimi
Louis Lefebvre
Tomohiro Kono
Matthew C. Lorincz
author_facet Julie Brind’Amour
Hisato Kobayashi
Julien Richard Albert
Kenjiro Shirane
Akihiko Sakashita
Asuka Kamio
Aaron Bogutz
Tasuku Koike
Mohammad M. Karimi
Louis Lefebvre
Tomohiro Kono
Matthew C. Lorincz
author_sort Julie Brind’Amour
title LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
title_short LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
title_full LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
title_fullStr LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
title_full_unstemmed LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
title_sort ltr retrotransposons transcribed in oocytes drive species-specific and heritable changes in dna methylation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f09
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