LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with diverge...
Guardado en:
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f09 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:bee0bd7cd38c4fa6acd4a2ae886f0f09 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:bee0bd7cd38c4fa6acd4a2ae886f0f092021-12-02T16:56:55ZLTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation10.1038/s41467-018-05841-x2041-1723https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f092018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05841-xhttps://doaj.org/toc/2041-1723De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs.Julie Brind’AmourHisato KobayashiJulien Richard AlbertKenjiro ShiraneAkihiko SakashitaAsuka KamioAaron BogutzTasuku KoikeMohammad M. KarimiLouis LefebvreTomohiro KonoMatthew C. LorinczNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Julie Brind’Amour Hisato Kobayashi Julien Richard Albert Kenjiro Shirane Akihiko Sakashita Asuka Kamio Aaron Bogutz Tasuku Koike Mohammad M. Karimi Louis Lefebvre Tomohiro Kono Matthew C. Lorincz LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation |
description |
De novo DNA methylation during mouse oogenesis occurs within transcribed regions. Here the authors investigate the role of species-specific long terminal repeats (LTRs)-initiated transcription units in regulating the oocyte methylome, identifying syntenic regions in mouse, rat and human with divergent DNA methylation associated with private LITs. |
format |
article |
author |
Julie Brind’Amour Hisato Kobayashi Julien Richard Albert Kenjiro Shirane Akihiko Sakashita Asuka Kamio Aaron Bogutz Tasuku Koike Mohammad M. Karimi Louis Lefebvre Tomohiro Kono Matthew C. Lorincz |
author_facet |
Julie Brind’Amour Hisato Kobayashi Julien Richard Albert Kenjiro Shirane Akihiko Sakashita Asuka Kamio Aaron Bogutz Tasuku Koike Mohammad M. Karimi Louis Lefebvre Tomohiro Kono Matthew C. Lorincz |
author_sort |
Julie Brind’Amour |
title |
LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation |
title_short |
LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation |
title_full |
LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation |
title_fullStr |
LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation |
title_full_unstemmed |
LTR retrotransposons transcribed in oocytes drive species-specific and heritable changes in DNA methylation |
title_sort |
ltr retrotransposons transcribed in oocytes drive species-specific and heritable changes in dna methylation |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/bee0bd7cd38c4fa6acd4a2ae886f0f09 |
work_keys_str_mv |
AT juliebrindamour ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT hisatokobayashi ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT julienrichardalbert ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT kenjiroshirane ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT akihikosakashita ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT asukakamio ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT aaronbogutz ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT tasukukoike ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT mohammadmkarimi ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT louislefebvre ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT tomohirokono ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation AT matthewclorincz ltrretrotransposonstranscribedinoocytesdrivespeciesspecificandheritablechangesindnamethylation |
_version_ |
1718382703646081024 |