Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography

Background: Inflammation plays a key role in atrial fibrillation (AF). Epicardial adipose tissue around the atrial wall can influence atrial morpho-functional properties. The aim of this study was to assess whether an increased quantity and/or density of adipose tissue located around the left atrium...

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Autores principales:	Nicola Gaibazzi, Chiara Martini, Giorgio Benatti, Alessandro Anselmo Palumbo, Giovanna Cacciola, Domenico Tuttolomondo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atrial fibrillation adipose tissue attenuation cardiac computed tomography angiography inflammation atrial size Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/bee1fa660ace417fa65aef3216ff0a36
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spelling	oai:doaj.org-article:bee1fa660ace417fa65aef3216ff0a362021-11-25T17:21:31ZAtrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography10.3390/diagnostics111120872075-4418https://doaj.org/article/bee1fa660ace417fa65aef3216ff0a362021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2087https://doaj.org/toc/2075-4418Background: Inflammation plays a key role in atrial fibrillation (AF). Epicardial adipose tissue around the atrial wall can influence atrial morpho-functional properties. The aim of this study was to assess whether an increased quantity and/or density of adipose tissue located around the left atrium (Fat-LA) are related to AF, independently from atrial size. Methods: eighty patients who underwent AF ablation and 80 patients without history of AF were selected. The Fat-LA mass was quantified as tissue within −190 to −30 Hounsfield Units (HU) on cardiac computed tomography angiograms (CCTA), and the mean adipose tissue attenuation was assessed. Results: Adipose tissue mass was higher in patients with AF (5.42 ± 2.94 mL) versus non-AF (4.16 ± 2.55 mL, <i>p</i> = 0.007), but relative fat quantity did not differ after adjusting for atrial size. Mean fat density was significantly higher in AF (−69.15 HU) versus non-AF (−76.82 HU, <i>p</i> < 0.0001) participants. In the logistic regression models, only the addition of mean Fat-LA attenuation led to a significant improvement of the model’s chi-square (from 22.89 of the clinical model to 31.69 of the clinical and adipose tissue attenuation model, <i>p</i> < 0.01) and discrimination (AUC from 0.775 to 0.829). Conclusions: Fat-LA volume is significantly greater only in absolute terms in patients with AF, but this difference does not hold after adjusting for the larger LA of AF subjects. On the contrary, a higher Fat-LA density was associated with AF, independently from LA size, providing incremental value over other variables that are associated with AF.Nicola GaibazziChiara MartiniGiorgio BenattiAlessandro Anselmo PalumboGiovanna CacciolaDomenico TuttolomondoMDPI AGarticleatrial fibrillationadipose tissue attenuationcardiac computed tomography angiographyinflammationatrial sizeMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2087, p 2087 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atrial fibrillation adipose tissue attenuation cardiac computed tomography angiography inflammation atrial size Medicine (General) R5-920
spellingShingle	atrial fibrillation adipose tissue attenuation cardiac computed tomography angiography inflammation atrial size Medicine (General) R5-920 Nicola Gaibazzi Chiara Martini Giorgio Benatti Alessandro Anselmo Palumbo Giovanna Cacciola Domenico Tuttolomondo Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography
description	Background: Inflammation plays a key role in atrial fibrillation (AF). Epicardial adipose tissue around the atrial wall can influence atrial morpho-functional properties. The aim of this study was to assess whether an increased quantity and/or density of adipose tissue located around the left atrium (Fat-LA) are related to AF, independently from atrial size. Methods: eighty patients who underwent AF ablation and 80 patients without history of AF were selected. The Fat-LA mass was quantified as tissue within −190 to −30 Hounsfield Units (HU) on cardiac computed tomography angiograms (CCTA), and the mean adipose tissue attenuation was assessed. Results: Adipose tissue mass was higher in patients with AF (5.42 ± 2.94 mL) versus non-AF (4.16 ± 2.55 mL, <i>p</i> = 0.007), but relative fat quantity did not differ after adjusting for atrial size. Mean fat density was significantly higher in AF (−69.15 HU) versus non-AF (−76.82 HU, <i>p</i> < 0.0001) participants. In the logistic regression models, only the addition of mean Fat-LA attenuation led to a significant improvement of the model’s chi-square (from 22.89 of the clinical model to 31.69 of the clinical and adipose tissue attenuation model, <i>p</i> < 0.01) and discrimination (AUC from 0.775 to 0.829). Conclusions: Fat-LA volume is significantly greater only in absolute terms in patients with AF, but this difference does not hold after adjusting for the larger LA of AF subjects. On the contrary, a higher Fat-LA density was associated with AF, independently from LA size, providing incremental value over other variables that are associated with AF.
format	article
author	Nicola Gaibazzi Chiara Martini Giorgio Benatti Alessandro Anselmo Palumbo Giovanna Cacciola Domenico Tuttolomondo
author_facet	Nicola Gaibazzi Chiara Martini Giorgio Benatti Alessandro Anselmo Palumbo Giovanna Cacciola Domenico Tuttolomondo
author_sort	Nicola Gaibazzi
title	Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography
title_short	Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography
title_full	Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography
title_fullStr	Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography
title_full_unstemmed	Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography
title_sort	atrial fibrillation and peri-atrial inflammation measured through adipose tissue attenuation on cardiac computed tomography
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bee1fa660ace417fa65aef3216ff0a36
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Atrial Fibrillation and Peri-Atrial Inflammation Measured through Adipose Tissue Attenuation on Cardiac Computed Tomography

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