Extreme value theory as a framework for understanding mutation frequency distribution in cancer genomes.
Currently, the population dynamics of preclonal cancer cells before clonal expansion of tumors has not been sufficiently addressed thus far. By focusing on preclonal cancer cell population as a Darwinian evolutionary system, we formulated and analyzed the observed mutation frequency among tumors (MF...
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Autores principales: | Natsuki Tokutomi, Kenta Nakai, Sumio Sugano |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/bee21620b9b544ea83d241c7d30f9bef |
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