Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI

Radiation-induced injury is damage to normal tissues caused by unintentional exposure to ionizing radiation. Image-based evaluation of tissue damage by irradiation has an advantage for the early assessment of therapeutic effects by providing sensitive information on minute tissue responses in situ....

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Autores principales:	Jin-Woong Kim, Ji-Ae Park, Nitish Katoch, Ji-ung Yang, Seungwoo Park, Bup-Kyung Choi, Sang-Gook Song, Tae-Hoon Kim, Hyung-Joong Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radiation therapy electrical conductivity ionizing radiation tissue response magnetic resonance imaging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bee21905cb644a88be1325e3ab5fc1b1
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spelling	oai:doaj.org-article:bee21905cb644a88be1325e3ab5fc1b12021-11-11T15:33:42ZImage-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI10.3390/cancers132154902072-6694https://doaj.org/article/bee21905cb644a88be1325e3ab5fc1b12021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5490https://doaj.org/toc/2072-6694Radiation-induced injury is damage to normal tissues caused by unintentional exposure to ionizing radiation. Image-based evaluation of tissue damage by irradiation has an advantage for the early assessment of therapeutic effects by providing sensitive information on minute tissue responses in situ. Recent magnetic resonance (MR)-based electrical conductivity imaging has shown potential as an effective early imaging biomarker for treatment response and radiation-induced injury. However, to be a tool for evaluating therapeutic effects, validation of its reliability and sensitivity according to various irradiation conditions is required. We performed MR-based electrical conductivity imaging on designed phantoms to confirm the effect of ionizing radiation at different doses and on in vivo mouse brains to distinguish tissue response depending on different doses and the elapsed time after irradiation. To quantify the irradiation effects, we measured the absolute conductivity of brain tissues and calculated relative conductivity changes based on the value of pre-irradiation. The conductivity of the phantoms with the distilled water and saline solution increased linearly with the irradiation doses. The conductivity of in vivo mouse brains showed different time-course variations and residual contrast depending on the irradiation doses. Future studies will focus on validation at long-term time points, including early and late delayed response and evaluation of irradiation effects in various tissue types.Jin-Woong KimJi-Ae ParkNitish KatochJi-ung YangSeungwoo ParkBup-Kyung ChoiSang-Gook SongTae-Hoon KimHyung-Joong KimMDPI AGarticleradiation therapyelectrical conductivityionizing radiationtissue responsemagnetic resonance imagingNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5490, p 5490 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radiation therapy electrical conductivity ionizing radiation tissue response magnetic resonance imaging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	radiation therapy electrical conductivity ionizing radiation tissue response magnetic resonance imaging Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jin-Woong Kim Ji-Ae Park Nitish Katoch Ji-ung Yang Seungwoo Park Bup-Kyung Choi Sang-Gook Song Tae-Hoon Kim Hyung-Joong Kim Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI
description	Radiation-induced injury is damage to normal tissues caused by unintentional exposure to ionizing radiation. Image-based evaluation of tissue damage by irradiation has an advantage for the early assessment of therapeutic effects by providing sensitive information on minute tissue responses in situ. Recent magnetic resonance (MR)-based electrical conductivity imaging has shown potential as an effective early imaging biomarker for treatment response and radiation-induced injury. However, to be a tool for evaluating therapeutic effects, validation of its reliability and sensitivity according to various irradiation conditions is required. We performed MR-based electrical conductivity imaging on designed phantoms to confirm the effect of ionizing radiation at different doses and on in vivo mouse brains to distinguish tissue response depending on different doses and the elapsed time after irradiation. To quantify the irradiation effects, we measured the absolute conductivity of brain tissues and calculated relative conductivity changes based on the value of pre-irradiation. The conductivity of the phantoms with the distilled water and saline solution increased linearly with the irradiation doses. The conductivity of in vivo mouse brains showed different time-course variations and residual contrast depending on the irradiation doses. Future studies will focus on validation at long-term time points, including early and late delayed response and evaluation of irradiation effects in various tissue types.
format	article
author	Jin-Woong Kim Ji-Ae Park Nitish Katoch Ji-ung Yang Seungwoo Park Bup-Kyung Choi Sang-Gook Song Tae-Hoon Kim Hyung-Joong Kim
author_facet	Jin-Woong Kim Ji-Ae Park Nitish Katoch Ji-ung Yang Seungwoo Park Bup-Kyung Choi Sang-Gook Song Tae-Hoon Kim Hyung-Joong Kim
author_sort	Jin-Woong Kim
title	Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI
title_short	Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI
title_full	Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI
title_fullStr	Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI
title_full_unstemmed	Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI
title_sort	image-based evaluation of irradiation effects in brain tissues by measuring absolute electrical conductivity using mri
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bee21905cb644a88be1325e3ab5fc1b1
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Image-Based Evaluation of Irradiation Effects in Brain Tissues by Measuring Absolute Electrical Conductivity Using MRI

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