E2F-dependent transcription determines replication capacity and S phase length

DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.

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Detalles Bibliográficos
Autores principales: Betheney R. Pennycook, Eva Vesela, Silvia Peripolli, Tanya Singh, Alexis R. Barr, Cosetta Bertoli, Robertus A. M. de Bruin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/bee6fa4381464a1ea5a0b25db67a1e23
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Descripción
Sumario:DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.