E2F-dependent transcription determines replication capacity and S phase length
DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.
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| Main Authors: | , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2020
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| Subjects: | |
| Online Access: | https://doaj.org/article/bee6fa4381464a1ea5a0b25db67a1e23 |
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| Summary: | DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase. |
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