E2F-dependent transcription determines replication capacity and S phase length

DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.

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Autores principales:	Betheney R. Pennycook, Eva Vesela, Silvia Peripolli, Tanya Singh, Alexis R. Barr, Cosetta Bertoli, Robertus A. M. de Bruin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bee6fa4381464a1ea5a0b25db67a1e23
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spelling	oai:doaj.org-article:bee6fa4381464a1ea5a0b25db67a1e232021-12-02T16:08:14ZE2F-dependent transcription determines replication capacity and S phase length10.1038/s41467-020-17146-z2041-1723https://doaj.org/article/bee6fa4381464a1ea5a0b25db67a1e232020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17146-zhttps://doaj.org/toc/2041-1723DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.Betheney R. PennycookEva VeselaSilvia PeripolliTanya SinghAlexis R. BarrCosetta BertoliRobertus A. M. de BruinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Betheney R. Pennycook Eva Vesela Silvia Peripolli Tanya Singh Alexis R. Barr Cosetta Bertoli Robertus A. M. de Bruin E2F-dependent transcription determines replication capacity and S phase length
description	DNA replication is tightly regulated during S phase of the cell cycle to ensure timely and accurate genome duplication. Here, the authors reveal that E2F-dependent transcription determines the maximal amount of DNA a cell is able to synthesise per unit time throughout S phase.
format	article
author	Betheney R. Pennycook Eva Vesela Silvia Peripolli Tanya Singh Alexis R. Barr Cosetta Bertoli Robertus A. M. de Bruin
author_facet	Betheney R. Pennycook Eva Vesela Silvia Peripolli Tanya Singh Alexis R. Barr Cosetta Bertoli Robertus A. M. de Bruin
author_sort	Betheney R. Pennycook
title	E2F-dependent transcription determines replication capacity and S phase length
title_short	E2F-dependent transcription determines replication capacity and S phase length
title_full	E2F-dependent transcription determines replication capacity and S phase length
title_fullStr	E2F-dependent transcription determines replication capacity and S phase length
title_full_unstemmed	E2F-dependent transcription determines replication capacity and S phase length
title_sort	e2f-dependent transcription determines replication capacity and s phase length
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/bee6fa4381464a1ea5a0b25db67a1e23
work_keys_str_mv	AT betheneyrpennycook e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength AT evavesela e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength AT silviaperipolli e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength AT tanyasingh e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength AT alexisrbarr e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength AT cosettabertoli e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength AT robertusamdebruin e2fdependenttranscriptiondeterminesreplicationcapacityandsphaselength
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E2F-dependent transcription determines replication capacity and S phase length

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