Evaluation of pulmonary function in patients with Thalassemia major

Background and Objective: The life time of patients with Thalassemia major has been considerably increased in recent years. Long-term complications such as liver and heart complications that caused by hemosiderosis create some problems for these patients. This study was done to evaluate the long-ter...

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Autores principales:	khA Bijani, A , Tamaddoni, R Ghadimi, R Hamzeh Pour
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2003
Materias:	thalassemia major pulmonary function test restrictive pattern obstructive pattern desferral Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/beece592ca74491b90df30c11196d334
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spelling	oai:doaj.org-article:beece592ca74491b90df30c11196d3342021-11-10T09:18:01ZEvaluation of pulmonary function in patients with Thalassemia major1561-41072251-7170https://doaj.org/article/beece592ca74491b90df30c11196d3342003-01-01T00:00:00Zhttp://jbums.org/article-1-2799-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: The life time of patients with Thalassemia major has been considerably increased in recent years. Long-term complications such as liver and heart complications that caused by hemosiderosis create some problems for these patients. This study was done to evaluate the long-term effects of this disease on lung tissue by pulmonary function test. Methods: This analytical study was performed on 91 normal persons and 100 patients with Thalassemia (Over 5 years old) who referred to Thalassemia research center. Both groups were matched according to their gender and age. After physical examination, ferritin was measured and chest X-ray and spirometry were taken for all persons in both groups. Parameters of pulmonary function test between two groups were compared and P<0.05 was considered as a significant level in test. Findings: Patients with Thalassemia had regular transfusion and 94% of cases received desferral. Spirometric results in 63% of persons in case group and 75.8% in control group were normal. Spirometric dysfunction in case group was as a restrictive pattern (37%) and obstructive pattern was not seen. In control group, 15.4% and 8.8% of persons had restrictive and obstructive patterns, respectively. Also, simultaneous using that due to decrease of desferrioxamine limits the pulmonary function test. Meanwhile pulmonary function abnormality in females was more severe than males (P<0.0001). Conclusion: Restrictive pattern was the most common spirometric dysfunction in patients with Thalassemia. Pulmonary complications of this disease can be reduced by using desferral.khA BijaniA , TamaddoniR GhadimiR Hamzeh PourBabol University of Medical Sciencesarticlethalassemia majorpulmonary function testrestrictive patternobstructive patterndesferralMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 5, Iss 1, Pp 36-40 (2003)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	thalassemia major pulmonary function test restrictive pattern obstructive pattern desferral Medicine R Medicine (General) R5-920
spellingShingle	thalassemia major pulmonary function test restrictive pattern obstructive pattern desferral Medicine R Medicine (General) R5-920 khA Bijani A , Tamaddoni R Ghadimi R Hamzeh Pour Evaluation of pulmonary function in patients with Thalassemia major
description	Background and Objective: The life time of patients with Thalassemia major has been considerably increased in recent years. Long-term complications such as liver and heart complications that caused by hemosiderosis create some problems for these patients. This study was done to evaluate the long-term effects of this disease on lung tissue by pulmonary function test. Methods: This analytical study was performed on 91 normal persons and 100 patients with Thalassemia (Over 5 years old) who referred to Thalassemia research center. Both groups were matched according to their gender and age. After physical examination, ferritin was measured and chest X-ray and spirometry were taken for all persons in both groups. Parameters of pulmonary function test between two groups were compared and P<0.05 was considered as a significant level in test. Findings: Patients with Thalassemia had regular transfusion and 94% of cases received desferral. Spirometric results in 63% of persons in case group and 75.8% in control group were normal. Spirometric dysfunction in case group was as a restrictive pattern (37%) and obstructive pattern was not seen. In control group, 15.4% and 8.8% of persons had restrictive and obstructive patterns, respectively. Also, simultaneous using that due to decrease of desferrioxamine limits the pulmonary function test. Meanwhile pulmonary function abnormality in females was more severe than males (P<0.0001). Conclusion: Restrictive pattern was the most common spirometric dysfunction in patients with Thalassemia. Pulmonary complications of this disease can be reduced by using desferral.
format	article
author	khA Bijani A , Tamaddoni R Ghadimi R Hamzeh Pour
author_facet	khA Bijani A , Tamaddoni R Ghadimi R Hamzeh Pour
author_sort	khA Bijani
title	Evaluation of pulmonary function in patients with Thalassemia major
title_short	Evaluation of pulmonary function in patients with Thalassemia major
title_full	Evaluation of pulmonary function in patients with Thalassemia major
title_fullStr	Evaluation of pulmonary function in patients with Thalassemia major
title_full_unstemmed	Evaluation of pulmonary function in patients with Thalassemia major
title_sort	evaluation of pulmonary function in patients with thalassemia major
publisher	Babol University of Medical Sciences
publishDate	2003
url	https://doaj.org/article/beece592ca74491b90df30c11196d334
work_keys_str_mv	AT khabijani evaluationofpulmonaryfunctioninpatientswiththalassemiamajor AT atamaddoni evaluationofpulmonaryfunctioninpatientswiththalassemiamajor AT rghadimi evaluationofpulmonaryfunctioninpatientswiththalassemiamajor AT rhamzehpour evaluationofpulmonaryfunctioninpatientswiththalassemiamajor
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Evaluation of pulmonary function in patients with Thalassemia major

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