Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients

Introduction: Coronary artery diseases (CAD) are still among the top causes of death in most populations. The polymorphisms of the cholesteryl ester transfer protein (CETP) gene can influence the risk of CAD through modulating cholesterol metabolism. In this regard, the current study aimed to determ...

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Autores principales:	Saeid Morovvati, Nima Kazemi Koohbanani, Iman Salahshouri Far, Fatemeh Karami
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2020
Materias:	cetp gene rs5882 rs708272 polymorphism coronary artery disease Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/beef3493dd88489586d0276bb61b7216
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spelling	oai:doaj.org-article:beef3493dd88489586d0276bb61b72162021-11-17T09:54:38ZGenotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients2476-664X10.34172/ijbsm.2020.17https://doaj.org/article/beef3493dd88489586d0276bb61b72162020-09-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-18413https://doaj.org/toc/2476-664XIntroduction: Coronary artery diseases (CAD) are still among the top causes of death in most populations. The polymorphisms of the cholesteryl ester transfer protein (CETP) gene can influence the risk of CAD through modulating cholesterol metabolism. In this regard, the current study aimed to determine the role of the 2 important CETP gene polymorphisms in CAD patients. Methods: To this end, DNA was extracted from the whole blood of 100 CAD patients and 100 healthy controls and then subjected to polymerase chain reaction-restriction fragment length polymorphism for the genotyping of rs5882 and rs708272 polymorphisms.Results: Based on the results, no meaningful association was found between rs5882 and rs708272 polymorphisms, neither separately nor in combination, and the risk of CAD. However, the risk of CAD significantly increased in male rs5882 polymorphism carriers (P = 0.01). Finally, no significant association was demonstrated between serum high-density lipoprotein levels and the genotypes or alleles of neither rs5882 nor rs708272 polymorphism. Conclusion: Despite the finding regarding the lack of an association between CAD and the studied polymorphisms of the CETP gene, the importance of those variants in CETP protein function and CAD pathogenesis warrants further investigation on larger populations.Saeid MorovvatiNima Kazemi KoohbananiIman Salahshouri FarFatemeh KaramiZabol University of Medical sciencesarticlecetp gene rs5882 rs708272 polymorphism coronary artery disease Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 5, Iss 3, Pp 96-100 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cetp gene rs5882 rs708272 polymorphism coronary artery disease Medicine (General) R5-920
spellingShingle	cetp gene rs5882 rs708272 polymorphism coronary artery disease Medicine (General) R5-920 Saeid Morovvati Nima Kazemi Koohbanani Iman Salahshouri Far Fatemeh Karami Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients
description	Introduction: Coronary artery diseases (CAD) are still among the top causes of death in most populations. The polymorphisms of the cholesteryl ester transfer protein (CETP) gene can influence the risk of CAD through modulating cholesterol metabolism. In this regard, the current study aimed to determine the role of the 2 important CETP gene polymorphisms in CAD patients. Methods: To this end, DNA was extracted from the whole blood of 100 CAD patients and 100 healthy controls and then subjected to polymerase chain reaction-restriction fragment length polymorphism for the genotyping of rs5882 and rs708272 polymorphisms.Results: Based on the results, no meaningful association was found between rs5882 and rs708272 polymorphisms, neither separately nor in combination, and the risk of CAD. However, the risk of CAD significantly increased in male rs5882 polymorphism carriers (P = 0.01). Finally, no significant association was demonstrated between serum high-density lipoprotein levels and the genotypes or alleles of neither rs5882 nor rs708272 polymorphism. Conclusion: Despite the finding regarding the lack of an association between CAD and the studied polymorphisms of the CETP gene, the importance of those variants in CETP protein function and CAD pathogenesis warrants further investigation on larger populations.
format	article
author	Saeid Morovvati Nima Kazemi Koohbanani Iman Salahshouri Far Fatemeh Karami
author_facet	Saeid Morovvati Nima Kazemi Koohbanani Iman Salahshouri Far Fatemeh Karami
author_sort	Saeid Morovvati
title	Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients
title_short	Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients
title_full	Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients
title_fullStr	Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients
title_full_unstemmed	Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients
title_sort	genotyping of 2 cholesteryl ester transfer protein gene variants among coronary artery disease patients
publisher	Zabol University of Medical sciences
publishDate	2020
url	https://doaj.org/article/beef3493dd88489586d0276bb61b7216
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Genotyping of 2 Cholesteryl Ester Transfer Protein Gene Variants Among Coronary Artery Disease Patients

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