ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease

Abstracts Alzheimer’s disease (AD) is a neurodegenerative disorder and is represented by complicated biological mechanisms and complexity of brain tissue. Our understanding of the complicated molecular architecture that contributes to AD progression benefits from performing comprehensive and systemi...

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Autores principales:	Seonggyun Han, Jaehang Shin, Hyeim Jung, Jane Ryu, Habtamu Minassie, Kwangsik Nho, Insong Koh, Younghee Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bef16bdea32147e7a59a34a22677cf7a
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spelling	oai:doaj.org-article:bef16bdea32147e7a59a34a22677cf7a2021-12-02T11:39:39ZADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease10.1038/s41540-021-00177-72056-7189https://doaj.org/article/bef16bdea32147e7a59a34a22677cf7a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41540-021-00177-7https://doaj.org/toc/2056-7189Abstracts Alzheimer’s disease (AD) is a neurodegenerative disorder and is represented by complicated biological mechanisms and complexity of brain tissue. Our understanding of the complicated molecular architecture that contributes to AD progression benefits from performing comprehensive and systemic investigations with multi-layered molecular and biological data from different brain regions. Since recently different independent studies generated various omics data in different brain regions of AD patients, multi-omics data integration can be a useful resource for better comprehensive understanding of AD. Here we present a web platform, ADAS-viewer, that provides researchers with the ability to comprehensively investigate and visualize multi-omics data from multiple brain regions of AD patients. ADAS-viewer offers means to identify functional changes in transcript and exon expression (i.e., alternative splicing) along with associated genetic or epigenetic regulatory effects. Specifically, it integrates genomic, transcriptomic, methylation, and miRNA data collected from seven different brain regions (cerebellum, temporal cortex, dorsolateral prefrontal cortex, frontal pole, inferior frontal gyrus, parahippocampal gyrus, and superior temporal gyrus) across three independent cohort datasets. ADAS-viewer is particularly useful as a web-based application for analyzing and visualizing multi-omics data across multiple brain regions at both transcript and exon level, allowing the identification of candidate biomarkers of Alzheimer’s disease.Seonggyun HanJaehang ShinHyeim JungJane RyuHabtamu MinassieKwangsik NhoInsong KohYounghee LeeNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Seonggyun Han Jaehang Shin Hyeim Jung Jane Ryu Habtamu Minassie Kwangsik Nho Insong Koh Younghee Lee ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
description	Abstracts Alzheimer’s disease (AD) is a neurodegenerative disorder and is represented by complicated biological mechanisms and complexity of brain tissue. Our understanding of the complicated molecular architecture that contributes to AD progression benefits from performing comprehensive and systemic investigations with multi-layered molecular and biological data from different brain regions. Since recently different independent studies generated various omics data in different brain regions of AD patients, multi-omics data integration can be a useful resource for better comprehensive understanding of AD. Here we present a web platform, ADAS-viewer, that provides researchers with the ability to comprehensively investigate and visualize multi-omics data from multiple brain regions of AD patients. ADAS-viewer offers means to identify functional changes in transcript and exon expression (i.e., alternative splicing) along with associated genetic or epigenetic regulatory effects. Specifically, it integrates genomic, transcriptomic, methylation, and miRNA data collected from seven different brain regions (cerebellum, temporal cortex, dorsolateral prefrontal cortex, frontal pole, inferior frontal gyrus, parahippocampal gyrus, and superior temporal gyrus) across three independent cohort datasets. ADAS-viewer is particularly useful as a web-based application for analyzing and visualizing multi-omics data across multiple brain regions at both transcript and exon level, allowing the identification of candidate biomarkers of Alzheimer’s disease.
format	article
author	Seonggyun Han Jaehang Shin Hyeim Jung Jane Ryu Habtamu Minassie Kwangsik Nho Insong Koh Younghee Lee
author_facet	Seonggyun Han Jaehang Shin Hyeim Jung Jane Ryu Habtamu Minassie Kwangsik Nho Insong Koh Younghee Lee
author_sort	Seonggyun Han
title	ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
title_short	ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
title_full	ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
title_fullStr	ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
title_full_unstemmed	ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease
title_sort	adas-viewer: web-based application for integrative analysis of multi-omics data in alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bef16bdea32147e7a59a34a22677cf7a
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ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease

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