Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.

<h4>Settings</h4>Kerala State, India has reported the greatest dual burden of Tuberculosis (TB) and Diabetes Mellitus (DM). Malappuram district in Kerala has monitored and recorded DM status and its control from 2010 under Revised National Tuberculosis Control Program (RNTCP).<h4>O...

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Autores principales:	Nandakumar K V, Karthickeyan Duraisamy, Shibu Balakrishnan, Sunilkumar M, Jaya Sankar S, Karuna D Sagili, Srinath Satyanarayana, Ajay Kumar M V, Donald A Enarson
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bef264bf0d27411ba6ef431883459859
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spelling	oai:doaj.org-article:bef264bf0d27411ba6ef4318834598592021-11-18T08:51:16ZOutcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.1932-620310.1371/journal.pone.0076275https://doaj.org/article/bef264bf0d27411ba6ef4318834598592013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24155897/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Settings</h4>Kerala State, India has reported the greatest dual burden of Tuberculosis (TB) and Diabetes Mellitus (DM). Malappuram district in Kerala has monitored and recorded DM status and its control from 2010 under Revised National Tuberculosis Control Program (RNTCP).<h4>Objectives</h4>To assess, under programme conditions, comprehensiveness of recording DM status among TB cases and the TB treatment outcomes among DM patients (disaggregated by glycemic control) and compare with-non DM patients.<h4>Design</h4>This retrospective record review included 3,116TB patients from April 2010 to September 2011.DM was defined as per international guidelines and TB treatment outcomes were categorized as favourable(cured and treatment completed) and unfavourable(death, default, failure and transfer out). Relative Risk (RR) and 95% confidence intervals(CI) were calculated to assess the risk of unfavourable outcomes.<h4>Results</h4>DM status was recorded in 90% of TB cases and 667 (24%) had DM. 17% of DM patients and 23% of patients with unknown DM status had unfavourable outcomes but this difference was not statistically significant. Unadjusted RR for poor glycemic control or unknown control status for unfavourable outcome were (2.00; 95% CI 0.97-4.13) and (2.14; 95% CI 1.11-4.13).<h4>Conclusion</h4>This study could not confirm an adverse association between DM or its control during treatment and the course of response to TB treatment.DM screening in TB cases and recording of DM care needs to be improved to enable more conclusive evidence.Nandakumar K VKarthickeyan DuraisamyShibu BalakrishnanSunilkumar MJaya Sankar SKaruna D SagiliSrinath SatyanarayanaAjay Kumar M VDonald A EnarsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76275 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nandakumar K V Karthickeyan Duraisamy Shibu Balakrishnan Sunilkumar M Jaya Sankar S Karuna D Sagili Srinath Satyanarayana Ajay Kumar M V Donald A Enarson Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.
description	<h4>Settings</h4>Kerala State, India has reported the greatest dual burden of Tuberculosis (TB) and Diabetes Mellitus (DM). Malappuram district in Kerala has monitored and recorded DM status and its control from 2010 under Revised National Tuberculosis Control Program (RNTCP).<h4>Objectives</h4>To assess, under programme conditions, comprehensiveness of recording DM status among TB cases and the TB treatment outcomes among DM patients (disaggregated by glycemic control) and compare with-non DM patients.<h4>Design</h4>This retrospective record review included 3,116TB patients from April 2010 to September 2011.DM was defined as per international guidelines and TB treatment outcomes were categorized as favourable(cured and treatment completed) and unfavourable(death, default, failure and transfer out). Relative Risk (RR) and 95% confidence intervals(CI) were calculated to assess the risk of unfavourable outcomes.<h4>Results</h4>DM status was recorded in 90% of TB cases and 667 (24%) had DM. 17% of DM patients and 23% of patients with unknown DM status had unfavourable outcomes but this difference was not statistically significant. Unadjusted RR for poor glycemic control or unknown control status for unfavourable outcome were (2.00; 95% CI 0.97-4.13) and (2.14; 95% CI 1.11-4.13).<h4>Conclusion</h4>This study could not confirm an adverse association between DM or its control during treatment and the course of response to TB treatment.DM screening in TB cases and recording of DM care needs to be improved to enable more conclusive evidence.
format	article
author	Nandakumar K V Karthickeyan Duraisamy Shibu Balakrishnan Sunilkumar M Jaya Sankar S Karuna D Sagili Srinath Satyanarayana Ajay Kumar M V Donald A Enarson
author_facet	Nandakumar K V Karthickeyan Duraisamy Shibu Balakrishnan Sunilkumar M Jaya Sankar S Karuna D Sagili Srinath Satyanarayana Ajay Kumar M V Donald A Enarson
author_sort	Nandakumar K V
title	Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.
title_short	Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.
title_full	Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.
title_fullStr	Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.
title_full_unstemmed	Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.
title_sort	outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in malappuram district, kerala, india.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bef264bf0d27411ba6ef431883459859
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Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India.

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