Classification of non-small cell lung cancer based on copy number alterations.

Lung cancer is one of the leading causes of cancer mortality worldwide and non-small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In t...

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Autores principales:	Bi-Qing Li, Jin You, Tao Huang, Yu-Dong Cai
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bef3a81441ce428e80689bc430b7016b
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spelling	oai:doaj.org-article:bef3a81441ce428e80689bc430b7016b2021-11-18T08:33:34ZClassification of non-small cell lung cancer based on copy number alterations.1932-620310.1371/journal.pone.0088300https://doaj.org/article/bef3a81441ce428e80689bc430b7016b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24505469/?tool=EBIhttps://doaj.org/toc/1932-6203Lung cancer is one of the leading causes of cancer mortality worldwide and non-small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In this study, we compared the genome-wide copy number alterations (CNAs) patterns of 208 early stage ACA and 93 early stage SCC tumor samples. As a result, 266 CNA probes stood out for better discrimination of ACA and SCC. It was revealed that the genes corresponding to these 266 probes were enriched in lung cancer related pathways and enriched in the chromosome regions where CNA usually occur in lung cancer. This study sheds lights on the CNA study of NSCLC and provides some insights on the epigenetic of NSCLC.Bi-Qing LiJin YouTao HuangYu-Dong CaiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e88300 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bi-Qing Li Jin You Tao Huang Yu-Dong Cai Classification of non-small cell lung cancer based on copy number alterations.
description	Lung cancer is one of the leading causes of cancer mortality worldwide and non-small cell lung cancer (NSCLC) accounts for the most part. NSCLC can be further divided into adenocarcinoma (ACA) and squamous cell carcinoma (SCC). It is of great value to distinguish these two subgroups clinically. In this study, we compared the genome-wide copy number alterations (CNAs) patterns of 208 early stage ACA and 93 early stage SCC tumor samples. As a result, 266 CNA probes stood out for better discrimination of ACA and SCC. It was revealed that the genes corresponding to these 266 probes were enriched in lung cancer related pathways and enriched in the chromosome regions where CNA usually occur in lung cancer. This study sheds lights on the CNA study of NSCLC and provides some insights on the epigenetic of NSCLC.
format	article
author	Bi-Qing Li Jin You Tao Huang Yu-Dong Cai
author_facet	Bi-Qing Li Jin You Tao Huang Yu-Dong Cai
author_sort	Bi-Qing Li
title	Classification of non-small cell lung cancer based on copy number alterations.
title_short	Classification of non-small cell lung cancer based on copy number alterations.
title_full	Classification of non-small cell lung cancer based on copy number alterations.
title_fullStr	Classification of non-small cell lung cancer based on copy number alterations.
title_full_unstemmed	Classification of non-small cell lung cancer based on copy number alterations.
title_sort	classification of non-small cell lung cancer based on copy number alterations.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/bef3a81441ce428e80689bc430b7016b
work_keys_str_mv	AT biqingli classificationofnonsmallcelllungcancerbasedoncopynumberalterations AT jinyou classificationofnonsmallcelllungcancerbasedoncopynumberalterations AT taohuang classificationofnonsmallcelllungcancerbasedoncopynumberalterations AT yudongcai classificationofnonsmallcelllungcancerbasedoncopynumberalterations
_version_	1718421644578390016

Classification of non-small cell lung cancer based on copy number alterations.

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