Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma

Abstract Background Novel treatments make long‐term survival possible for subsets of patients with melanoma brain metastases. Brain magnetic resonance imaging (MRI) may aid in early detection of brain metastases and inform treatment decisions. This study aimed to determine the impact of screening MR...

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Autores principales:	Annemarie C. Eggen, Thijs T. Wind, Ingeborg Bosma, Miranda C. A. Kramer, Peter Jan vanLaar, Hiska L. van derWeide, Geke A. P. Hospers, Mathilde Jalving
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	brain metastases early diagnosis melanoma neuroimaging neuro‐oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/bef6a4300a814097a36797f4f96af208
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spelling	oai:doaj.org-article:bef6a4300a814097a36797f4f96af2082021-12-01T04:49:15ZValue of screening and follow‐up brain MRI scans in patients with metastatic melanoma2045-763410.1002/cam4.4342https://doaj.org/article/bef6a4300a814097a36797f4f96af2082021-12-01T00:00:00Zhttps://doi.org/10.1002/cam4.4342https://doaj.org/toc/2045-7634Abstract Background Novel treatments make long‐term survival possible for subsets of patients with melanoma brain metastases. Brain magnetic resonance imaging (MRI) may aid in early detection of brain metastases and inform treatment decisions. This study aimed to determine the impact of screening MRI scans in patients with metastatic melanoma and follow‐up MRI scans in patients with melanoma brain metastases. Methods This retrospective cohort study included patients diagnosed with metastatic melanoma or melanoma brain metastases between June 2015 and January 2018. The impact of screening MRI scans was evaluated in the first 2 years after metastatic melanoma diagnosis. The impact of follow‐up MRI scans was examined in the first year after brain metastases diagnosis. The number of MRI scans, scan indications, scan outcomes, and changes in treatment strategy were analyzed. Results In total, 116 patients had no brain metastases at the time of the metastatic melanoma diagnosis. Twenty‐eight of these patients (24%) were subsequently diagnosed with brain metastases. Screening MRI scans detected the brain metastases in 11/28 patients (39%), of which 8 were asymptomatic at diagnosis. In the 96 patients with melanoma brain metastases, treatment strategy changed after 75/168 follow‐up MRI scans (45%). In patients treated with immune checkpoint inhibitors, the number of treatment changes after follow‐up MRI scans was lower when patients had been treated longer. Conclusion(s) Screening MRI scans aid in early detection of melanoma brain metastases, and follow‐up MRI scans inform treatment strategy. In patients with brain metastases responding to immune checkpoint inhibitors, treatment changes were less frequently observed after follow‐up MRI scans. These results can inform the development of brain imaging protocols for patients with immune checkpoint inhibitor sensitive tumors.Annemarie C. EggenThijs T. WindIngeborg BosmaMiranda C. A. KramerPeter Jan vanLaarHiska L. van derWeideGeke A. P. HospersMathilde JalvingWileyarticlebrain metastasesearly diagnosismelanomaneuroimagingneuro‐oncologyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 23, Pp 8395-8404 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain metastases early diagnosis melanoma neuroimaging neuro‐oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	brain metastases early diagnosis melanoma neuroimaging neuro‐oncology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Annemarie C. Eggen Thijs T. Wind Ingeborg Bosma Miranda C. A. Kramer Peter Jan vanLaar Hiska L. van derWeide Geke A. P. Hospers Mathilde Jalving Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma
description	Abstract Background Novel treatments make long‐term survival possible for subsets of patients with melanoma brain metastases. Brain magnetic resonance imaging (MRI) may aid in early detection of brain metastases and inform treatment decisions. This study aimed to determine the impact of screening MRI scans in patients with metastatic melanoma and follow‐up MRI scans in patients with melanoma brain metastases. Methods This retrospective cohort study included patients diagnosed with metastatic melanoma or melanoma brain metastases between June 2015 and January 2018. The impact of screening MRI scans was evaluated in the first 2 years after metastatic melanoma diagnosis. The impact of follow‐up MRI scans was examined in the first year after brain metastases diagnosis. The number of MRI scans, scan indications, scan outcomes, and changes in treatment strategy were analyzed. Results In total, 116 patients had no brain metastases at the time of the metastatic melanoma diagnosis. Twenty‐eight of these patients (24%) were subsequently diagnosed with brain metastases. Screening MRI scans detected the brain metastases in 11/28 patients (39%), of which 8 were asymptomatic at diagnosis. In the 96 patients with melanoma brain metastases, treatment strategy changed after 75/168 follow‐up MRI scans (45%). In patients treated with immune checkpoint inhibitors, the number of treatment changes after follow‐up MRI scans was lower when patients had been treated longer. Conclusion(s) Screening MRI scans aid in early detection of melanoma brain metastases, and follow‐up MRI scans inform treatment strategy. In patients with brain metastases responding to immune checkpoint inhibitors, treatment changes were less frequently observed after follow‐up MRI scans. These results can inform the development of brain imaging protocols for patients with immune checkpoint inhibitor sensitive tumors.
format	article
author	Annemarie C. Eggen Thijs T. Wind Ingeborg Bosma Miranda C. A. Kramer Peter Jan vanLaar Hiska L. van derWeide Geke A. P. Hospers Mathilde Jalving
author_facet	Annemarie C. Eggen Thijs T. Wind Ingeborg Bosma Miranda C. A. Kramer Peter Jan vanLaar Hiska L. van derWeide Geke A. P. Hospers Mathilde Jalving
author_sort	Annemarie C. Eggen
title	Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma
title_short	Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma
title_full	Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma
title_fullStr	Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma
title_full_unstemmed	Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma
title_sort	value of screening and follow‐up brain mri scans in patients with metastatic melanoma
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/bef6a4300a814097a36797f4f96af208
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Value of screening and follow‐up brain MRI scans in patients with metastatic melanoma

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