A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA

Objective: Primary extranodal non-Hodgkin's lymphoma (eNHL) usually presents at an early stage, as an extranodal organ involvement along with draining lymph nodes only or the predominant site is extranodal. As an eNHL, primary skeletal muscle lymphoma is very rare. The usual clinical picture is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Beyza OLUK, Metban MASTANZADE, Nur Seda IBILI, Sevgi KALAYOĞLU BEŞIŞIK
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/bef9507a581b47ca9cc0727687090a75
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:bef9507a581b47ca9cc0727687090a75
record_format	dspace
spelling	oai:doaj.org-article:bef9507a581b47ca9cc0727687090a752021-11-10T04:35:46ZA CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA2531-137910.1016/j.htct.2021.10.1032https://doaj.org/article/bef9507a581b47ca9cc0727687090a752021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2531137921011792https://doaj.org/toc/2531-1379Objective: Primary extranodal non-Hodgkin's lymphoma (eNHL) usually presents at an early stage, as an extranodal organ involvement along with draining lymph nodes only or the predominant site is extranodal. As an eNHL, primary skeletal muscle lymphoma is very rare. The usual clinical picture is local swelling and pain with or without systemic symptoms. MRI features are distinctive and FDG-PET/CT may help to evaluate the stage and monitor the response to the treatment. Case report: A 56-year-old male, presented with a one-month history of swelling and pain on his left ankle. There was no history of trauma or any physical strain. A mass lesion was palpated on the calcaneus bone. MRI showed diffuse muscle involvement. The clinical picture was not consistent with infection or hematoma. The blood cell count and biochemical investigations were within normal limits. Serology for hepatitis B, C and HIV were negative. Biopsy was decided. Methodology: Histological examination revealed CD19, CD20, bcl-2 and bcl-6 positive B-cell lymphoma with a Ki67 proliferation index of 95%. Myc, bcl-2, and bcl-6 gene rearrangements were not detected. Diffuse large B cell lymphoma was diagnosed. FDG-PET/CT showed lesions in multiple regions only limited to skeletal muscles but no other organ involvement. He had no adverse risk factors but bulky lesion (11cm sized lesion). After 6 courses of R-CHOP protocol, he had complete anatomic and metabolic response. Conclusion: Healthy skeletal muscles do not have lymphatic system. Lymphomatous involvement of muscles occurs by 3 pathways as dissemination via the haematogenous or lymphatic pathway, extension from adjacent organs, such as the bones or lymph nodes, and de novo primary extranodal disease. Most of the histology primary skeletal lymphomas have the aggressive B-cell immunophenoty. In general, treatment is similar to nodal lymphomas. In conclusion, we aimed to contribute in experience with this rare eNHL type.Beyza OLUKMetban MASTANZADENur Seda IBILISevgi KALAYOĞLU BEŞIŞIKElsevierarticleDiseases of the blood and blood-forming organsRC633-647.5ENHematology, Transfusion and Cell Therapy, Vol 43, Iss , Pp S41- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	Diseases of the blood and blood-forming organs RC633-647.5 Beyza OLUK Metban MASTANZADE Nur Seda IBILI Sevgi KALAYOĞLU BEŞIŞIK A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA
description	Objective: Primary extranodal non-Hodgkin's lymphoma (eNHL) usually presents at an early stage, as an extranodal organ involvement along with draining lymph nodes only or the predominant site is extranodal. As an eNHL, primary skeletal muscle lymphoma is very rare. The usual clinical picture is local swelling and pain with or without systemic symptoms. MRI features are distinctive and FDG-PET/CT may help to evaluate the stage and monitor the response to the treatment. Case report: A 56-year-old male, presented with a one-month history of swelling and pain on his left ankle. There was no history of trauma or any physical strain. A mass lesion was palpated on the calcaneus bone. MRI showed diffuse muscle involvement. The clinical picture was not consistent with infection or hematoma. The blood cell count and biochemical investigations were within normal limits. Serology for hepatitis B, C and HIV were negative. Biopsy was decided. Methodology: Histological examination revealed CD19, CD20, bcl-2 and bcl-6 positive B-cell lymphoma with a Ki67 proliferation index of 95%. Myc, bcl-2, and bcl-6 gene rearrangements were not detected. Diffuse large B cell lymphoma was diagnosed. FDG-PET/CT showed lesions in multiple regions only limited to skeletal muscles but no other organ involvement. He had no adverse risk factors but bulky lesion (11cm sized lesion). After 6 courses of R-CHOP protocol, he had complete anatomic and metabolic response. Conclusion: Healthy skeletal muscles do not have lymphatic system. Lymphomatous involvement of muscles occurs by 3 pathways as dissemination via the haematogenous or lymphatic pathway, extension from adjacent organs, such as the bones or lymph nodes, and de novo primary extranodal disease. Most of the histology primary skeletal lymphomas have the aggressive B-cell immunophenoty. In general, treatment is similar to nodal lymphomas. In conclusion, we aimed to contribute in experience with this rare eNHL type.
format	article
author	Beyza OLUK Metban MASTANZADE Nur Seda IBILI Sevgi KALAYOĞLU BEŞIŞIK
author_facet	Beyza OLUK Metban MASTANZADE Nur Seda IBILI Sevgi KALAYOĞLU BEŞIŞIK
author_sort	Beyza OLUK
title	A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA
title_short	A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA
title_full	A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA
title_fullStr	A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA
title_full_unstemmed	A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA
title_sort	case of multi regional primary muscle lymphoma
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/bef9507a581b47ca9cc0727687090a75
work_keys_str_mv	AT beyzaoluk acaseofmultiregionalprimarymusclelymphoma AT metbanmastanzade acaseofmultiregionalprimarymusclelymphoma AT nursedaibili acaseofmultiregionalprimarymusclelymphoma AT sevgikalayoglubesisik acaseofmultiregionalprimarymusclelymphoma AT beyzaoluk caseofmultiregionalprimarymusclelymphoma AT metbanmastanzade caseofmultiregionalprimarymusclelymphoma AT nursedaibili caseofmultiregionalprimarymusclelymphoma AT sevgikalayoglubesisik caseofmultiregionalprimarymusclelymphoma
_version_	1718440593617584128

A CASE OF MULTI REGIONAL PRIMARY MUSCLE LYMPHOMA

Ejemplares similares