Gene flow between the Korean peninsula and its neighboring countries.

SNP markers provide the primary data for population structure analysis. In this study, we employed whole-genome autosomal SNPs as a marker set (54,836 SNP markers) and tested their possible effects on genetic ancestry using 320 subjects covering 24 regional groups including Northern (=16) and Southe...

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Autores principales:	Jongsun Jung, Hoyoung Kang, Yoon Shin Cho, Ji Hee Oh, Min Hyung Ryu, Hye Won Chung, Jeong-Sun Seo, Jong-Eun Lee, Bermseok Oh, Jong Bhak, Hyung-Lae Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/befbdfa60c5b4a78854b6273cd5727de
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spelling	oai:doaj.org-article:befbdfa60c5b4a78854b6273cd5727de2021-11-18T06:36:35ZGene flow between the Korean peninsula and its neighboring countries.1932-620310.1371/journal.pone.0011855https://doaj.org/article/befbdfa60c5b4a78854b6273cd5727de2010-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20686617/?tool=EBIhttps://doaj.org/toc/1932-6203SNP markers provide the primary data for population structure analysis. In this study, we employed whole-genome autosomal SNPs as a marker set (54,836 SNP markers) and tested their possible effects on genetic ancestry using 320 subjects covering 24 regional groups including Northern (=16) and Southern (=3) Asians, Amerindians (=1), and four HapMap populations (YRI, CEU, JPT, and CHB). Additionally, we evaluated the effectiveness and robustness of 50K autosomal SNPs with various clustering methods, along with their dependencies on recombination hotspots (RH), linkage disequilibrium (LD), missing calls and regional specific markers. The RH- and LD-free multi-dimensional scaling (MDS) method showed a broad picture of human migration from Africa to North-East Asia on our genome map, supporting results from previous haploid DNA studies. Of the Asian groups, the East Asian group showed greater differentiation than the Northern and Southern Asian groups with respect to Fst statistics. By extension, the analysis of monomorphic markers implied that nine out of ten historical regions in South Korea, and Tokyo in Japan, showed signs of genetic drift caused by the later settlement of East Asia (South Korea, Japan and China), while Gyeongju in South East Korea showed signs of the earliest settlement in East Asia. In the genome map, the gene flow to the Korean Peninsula from its neighboring countries indicated that some genetic signals from Northern populations such as the Siberians and Mongolians still remain in the South East and West regions, while few signals remain from the early Southern lineages.Jongsun JungHoyoung KangYoon Shin ChoJi Hee OhMin Hyung RyuHye Won ChungJeong-Sun SeoJong-Eun LeeBermseok OhJong BhakHyung-Lae KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 7, p e11855 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jongsun Jung Hoyoung Kang Yoon Shin Cho Ji Hee Oh Min Hyung Ryu Hye Won Chung Jeong-Sun Seo Jong-Eun Lee Bermseok Oh Jong Bhak Hyung-Lae Kim Gene flow between the Korean peninsula and its neighboring countries.
description	SNP markers provide the primary data for population structure analysis. In this study, we employed whole-genome autosomal SNPs as a marker set (54,836 SNP markers) and tested their possible effects on genetic ancestry using 320 subjects covering 24 regional groups including Northern (=16) and Southern (=3) Asians, Amerindians (=1), and four HapMap populations (YRI, CEU, JPT, and CHB). Additionally, we evaluated the effectiveness and robustness of 50K autosomal SNPs with various clustering methods, along with their dependencies on recombination hotspots (RH), linkage disequilibrium (LD), missing calls and regional specific markers. The RH- and LD-free multi-dimensional scaling (MDS) method showed a broad picture of human migration from Africa to North-East Asia on our genome map, supporting results from previous haploid DNA studies. Of the Asian groups, the East Asian group showed greater differentiation than the Northern and Southern Asian groups with respect to Fst statistics. By extension, the analysis of monomorphic markers implied that nine out of ten historical regions in South Korea, and Tokyo in Japan, showed signs of genetic drift caused by the later settlement of East Asia (South Korea, Japan and China), while Gyeongju in South East Korea showed signs of the earliest settlement in East Asia. In the genome map, the gene flow to the Korean Peninsula from its neighboring countries indicated that some genetic signals from Northern populations such as the Siberians and Mongolians still remain in the South East and West regions, while few signals remain from the early Southern lineages.
format	article
author	Jongsun Jung Hoyoung Kang Yoon Shin Cho Ji Hee Oh Min Hyung Ryu Hye Won Chung Jeong-Sun Seo Jong-Eun Lee Bermseok Oh Jong Bhak Hyung-Lae Kim
author_facet	Jongsun Jung Hoyoung Kang Yoon Shin Cho Ji Hee Oh Min Hyung Ryu Hye Won Chung Jeong-Sun Seo Jong-Eun Lee Bermseok Oh Jong Bhak Hyung-Lae Kim
author_sort	Jongsun Jung
title	Gene flow between the Korean peninsula and its neighboring countries.
title_short	Gene flow between the Korean peninsula and its neighboring countries.
title_full	Gene flow between the Korean peninsula and its neighboring countries.
title_fullStr	Gene flow between the Korean peninsula and its neighboring countries.
title_full_unstemmed	Gene flow between the Korean peninsula and its neighboring countries.
title_sort	gene flow between the korean peninsula and its neighboring countries.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/befbdfa60c5b4a78854b6273cd5727de
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Gene flow between the Korean peninsula and its neighboring countries.

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