PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis

Increased glycolysis and inflammatory responses have been observed in endothelial cells exposed to disturbed flow. However, the role of endothelial glycolysis in atherosclerosis is unclear. Here the authors unveil a protective role for glycolysis by showing that endothelial deletion of Prkaa1 accele...

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Autores principales: Qiuhua Yang, Jiean Xu, Qian Ma, Zhiping Liu, Varadarajan Sudhahar, Yapeng Cao, Lina Wang, Xianqiu Zeng, Yaqi Zhou, Min Zhang, Yiming Xu, Yong Wang, Neal L. Weintraub, Chunxiang Zhang, Tohru Fukai, Chaodong Wu, Lei Huang, Zhen Han, Tao Wang, David J. Fulton, Mei Hong, Yuqing Huo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/befd6b37207d47fb8d266efd4020896c
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spelling oai:doaj.org-article:befd6b37207d47fb8d266efd4020896c2021-12-02T15:33:57ZPRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis10.1038/s41467-018-07132-x2041-1723https://doaj.org/article/befd6b37207d47fb8d266efd4020896c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07132-xhttps://doaj.org/toc/2041-1723Increased glycolysis and inflammatory responses have been observed in endothelial cells exposed to disturbed flow. However, the role of endothelial glycolysis in atherosclerosis is unclear. Here the authors unveil a protective role for glycolysis by showing that endothelial deletion of Prkaa1 accelerates atherosclerosis in hyperlipidemic mice through a reduction of glycolytic metabolism.Qiuhua YangJiean XuQian MaZhiping LiuVaradarajan SudhaharYapeng CaoLina WangXianqiu ZengYaqi ZhouMin ZhangYiming XuYong WangNeal L. WeintraubChunxiang ZhangTohru FukaiChaodong WuLei HuangZhen HanTao WangDavid J. FultonMei HongYuqing HuoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Qiuhua Yang
Jiean Xu
Qian Ma
Zhiping Liu
Varadarajan Sudhahar
Yapeng Cao
Lina Wang
Xianqiu Zeng
Yaqi Zhou
Min Zhang
Yiming Xu
Yong Wang
Neal L. Weintraub
Chunxiang Zhang
Tohru Fukai
Chaodong Wu
Lei Huang
Zhen Han
Tao Wang
David J. Fulton
Mei Hong
Yuqing Huo
PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
description Increased glycolysis and inflammatory responses have been observed in endothelial cells exposed to disturbed flow. However, the role of endothelial glycolysis in atherosclerosis is unclear. Here the authors unveil a protective role for glycolysis by showing that endothelial deletion of Prkaa1 accelerates atherosclerosis in hyperlipidemic mice through a reduction of glycolytic metabolism.
format article
author Qiuhua Yang
Jiean Xu
Qian Ma
Zhiping Liu
Varadarajan Sudhahar
Yapeng Cao
Lina Wang
Xianqiu Zeng
Yaqi Zhou
Min Zhang
Yiming Xu
Yong Wang
Neal L. Weintraub
Chunxiang Zhang
Tohru Fukai
Chaodong Wu
Lei Huang
Zhen Han
Tao Wang
David J. Fulton
Mei Hong
Yuqing Huo
author_facet Qiuhua Yang
Jiean Xu
Qian Ma
Zhiping Liu
Varadarajan Sudhahar
Yapeng Cao
Lina Wang
Xianqiu Zeng
Yaqi Zhou
Min Zhang
Yiming Xu
Yong Wang
Neal L. Weintraub
Chunxiang Zhang
Tohru Fukai
Chaodong Wu
Lei Huang
Zhen Han
Tao Wang
David J. Fulton
Mei Hong
Yuqing Huo
author_sort Qiuhua Yang
title PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
title_short PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
title_full PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
title_fullStr PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
title_full_unstemmed PRKAA1/AMPKα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
title_sort prkaa1/ampkα1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/befd6b37207d47fb8d266efd4020896c
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