A KRAS-responsive long non-coding RNA controls microRNA processing

A KRAS-responsive long non-coding RNA controls microRNA processing

Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may prevent KRAS-driven tumourigenesis.

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Auteurs principaux: Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brullé-Soumaré, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O’Keefe, Michela Garofalo
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/befd75df391041c7bcbc529acaf3af0c
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Résumé:Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may prevent KRAS-driven tumourigenesis.

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