A KRAS-responsive long non-coding RNA controls microRNA processing

Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may prevent KRAS-driven tumourigenesis.

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Autores principales:	Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brullé-Soumaré, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O’Keefe, Michela Garofalo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/befd75df391041c7bcbc529acaf3af0c
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spelling	oai:doaj.org-article:befd75df391041c7bcbc529acaf3af0c2021-12-02T14:23:03ZA KRAS-responsive long non-coding RNA controls microRNA processing10.1038/s41467-021-22337-32041-1723https://doaj.org/article/befd75df391041c7bcbc529acaf3af0c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22337-3https://doaj.org/toc/2041-1723Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may prevent KRAS-driven tumourigenesis.Lei ShiPeter MageeMatteo FassanSudhakar SahooHui Sun LeongDave LeeRobert SellersLaura Brullé-SoumaréStefano CairoTiziana MonteverdeStefano VoliniaDuncan D. SmithGianpiero Di LevaFrancesca GaluppiniAthanasios R. PaliourasKang ZengRaymond O’KeefeMichela GarofaloNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Shi Peter Magee Matteo Fassan Sudhakar Sahoo Hui Sun Leong Dave Lee Robert Sellers Laura Brullé-Soumaré Stefano Cairo Tiziana Monteverde Stefano Volinia Duncan D. Smith Gianpiero Di Leva Francesca Galuppini Athanasios R. Paliouras Kang Zeng Raymond O’Keefe Michela Garofalo A KRAS-responsive long non-coding RNA controls microRNA processing
description	Wild-type KRAS amplification is known to induce KRAS activation in cancer leading to poor prognostic outcomes. Here the authors identify a KRAS-responsive lncRNA, KIMAT1 that maintains KRAS signalling in lung cancer, suggesting that its targeting may prevent KRAS-driven tumourigenesis.
format	article
author	Lei Shi Peter Magee Matteo Fassan Sudhakar Sahoo Hui Sun Leong Dave Lee Robert Sellers Laura Brullé-Soumaré Stefano Cairo Tiziana Monteverde Stefano Volinia Duncan D. Smith Gianpiero Di Leva Francesca Galuppini Athanasios R. Paliouras Kang Zeng Raymond O’Keefe Michela Garofalo
author_facet	Lei Shi Peter Magee Matteo Fassan Sudhakar Sahoo Hui Sun Leong Dave Lee Robert Sellers Laura Brullé-Soumaré Stefano Cairo Tiziana Monteverde Stefano Volinia Duncan D. Smith Gianpiero Di Leva Francesca Galuppini Athanasios R. Paliouras Kang Zeng Raymond O’Keefe Michela Garofalo
author_sort	Lei Shi
title	A KRAS-responsive long non-coding RNA controls microRNA processing
title_short	A KRAS-responsive long non-coding RNA controls microRNA processing
title_full	A KRAS-responsive long non-coding RNA controls microRNA processing
title_fullStr	A KRAS-responsive long non-coding RNA controls microRNA processing
title_full_unstemmed	A KRAS-responsive long non-coding RNA controls microRNA processing
title_sort	kras-responsive long non-coding rna controls microrna processing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/befd75df391041c7bcbc529acaf3af0c
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A KRAS-responsive long non-coding RNA controls microRNA processing

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