Late maturation of adult-born neurons in the temporal dentate gyrus.

Hippocampal function varies along its septotemporal axis, with the septal (dorsal) pole more frequently involved in spatial learning and memory and the temporal (ventral) pole playing a greater role in emotional behaviors. One feature that varies across these subregions is adult neurogenesis. New ne...

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Autores principales:	Jason S Snyder, Sarah C Ferrante, Heather A Cameron
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/beff09d2c99a4551b8102174b369a954
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spelling	oai:doaj.org-article:beff09d2c99a4551b8102174b369a9542021-11-18T08:09:41ZLate maturation of adult-born neurons in the temporal dentate gyrus.1932-620310.1371/journal.pone.0048757https://doaj.org/article/beff09d2c99a4551b8102174b369a9542012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144957/?tool=EBIhttps://doaj.org/toc/1932-6203Hippocampal function varies along its septotemporal axis, with the septal (dorsal) pole more frequently involved in spatial learning and memory and the temporal (ventral) pole playing a greater role in emotional behaviors. One feature that varies across these subregions is adult neurogenesis. New neurons are more numerous in the septal hippocampus but are more active in the temporal hippocampus during water maze training. However, many other aspects of adult neurogenesis remain unexplored in the context of septal versus temporal subregions. In addition, the dentate gyrus contains another functionally important anatomical division along the transverse axis, with the suprapyramidal blade showing greater experience-related activity than the infrapyramidal blade. Here we ask whether new neurons differ in their rates of survival and maturation along the septotemporal and transverse axes. We found that neurogenesis is initially higher in the infrapyramidal than suprapyramidal blade, but these cells are less likely to survive, resulting in similar densities of neurons in the two blades by four weeks. Across the septotemporal axis, neurogenesis was higher in septal than temporal pole, while the survival rate of new neurons did not differ. Maturation was assessed by immunostaining for the neuronal marker, NeuN, which increases in expression level with maturation, and for the immediate-early gene, Arc, which suggests a neuron is capable of undergoing activity-dependent synaptic plasticity. Maturation occurred approximately 1-2 weeks earlier in the septal pole than in the temporal pole. This suggests that septal neurons may contribute to function sooner; however, the prolonged maturation of new temporal neurons may endow them with a longer window of plasticity during which their functions could be distinct from those of the mature granule cell population. These data point to subregional differences in new neuron maturation and suggest that changes in neurogenesis could alter different hippocampus-dependent behaviors with different time courses.Jason S SnyderSarah C FerranteHeather A CameronPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48757 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jason S Snyder Sarah C Ferrante Heather A Cameron Late maturation of adult-born neurons in the temporal dentate gyrus.
description	Hippocampal function varies along its septotemporal axis, with the septal (dorsal) pole more frequently involved in spatial learning and memory and the temporal (ventral) pole playing a greater role in emotional behaviors. One feature that varies across these subregions is adult neurogenesis. New neurons are more numerous in the septal hippocampus but are more active in the temporal hippocampus during water maze training. However, many other aspects of adult neurogenesis remain unexplored in the context of septal versus temporal subregions. In addition, the dentate gyrus contains another functionally important anatomical division along the transverse axis, with the suprapyramidal blade showing greater experience-related activity than the infrapyramidal blade. Here we ask whether new neurons differ in their rates of survival and maturation along the septotemporal and transverse axes. We found that neurogenesis is initially higher in the infrapyramidal than suprapyramidal blade, but these cells are less likely to survive, resulting in similar densities of neurons in the two blades by four weeks. Across the septotemporal axis, neurogenesis was higher in septal than temporal pole, while the survival rate of new neurons did not differ. Maturation was assessed by immunostaining for the neuronal marker, NeuN, which increases in expression level with maturation, and for the immediate-early gene, Arc, which suggests a neuron is capable of undergoing activity-dependent synaptic plasticity. Maturation occurred approximately 1-2 weeks earlier in the septal pole than in the temporal pole. This suggests that septal neurons may contribute to function sooner; however, the prolonged maturation of new temporal neurons may endow them with a longer window of plasticity during which their functions could be distinct from those of the mature granule cell population. These data point to subregional differences in new neuron maturation and suggest that changes in neurogenesis could alter different hippocampus-dependent behaviors with different time courses.
format	article
author	Jason S Snyder Sarah C Ferrante Heather A Cameron
author_facet	Jason S Snyder Sarah C Ferrante Heather A Cameron
author_sort	Jason S Snyder
title	Late maturation of adult-born neurons in the temporal dentate gyrus.
title_short	Late maturation of adult-born neurons in the temporal dentate gyrus.
title_full	Late maturation of adult-born neurons in the temporal dentate gyrus.
title_fullStr	Late maturation of adult-born neurons in the temporal dentate gyrus.
title_full_unstemmed	Late maturation of adult-born neurons in the temporal dentate gyrus.
title_sort	late maturation of adult-born neurons in the temporal dentate gyrus.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/beff09d2c99a4551b8102174b369a954
work_keys_str_mv	AT jasonssnyder latematurationofadultbornneuronsinthetemporaldentategyrus AT sarahcferrante latematurationofadultbornneuronsinthetemporaldentategyrus AT heatheracameron latematurationofadultbornneuronsinthetemporaldentategyrus
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Late maturation of adult-born neurons in the temporal dentate gyrus.

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