Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell viability in hypoxia are identified.

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Autores principales:	Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bf0028ba8d264de48beb6836642740d8
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spelling	oai:doaj.org-article:bf0028ba8d264de48beb6836642740d82021-12-02T15:45:15ZGenome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia10.1038/s42003-021-02098-x2399-3642https://doaj.org/article/bf0028ba8d264de48beb6836642740d82021-05-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02098-xhttps://doaj.org/toc/2399-3642Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell viability in hypoxia are identified.Luke W. ThomasCinzia EspositoRachel E. MorganStacey PriceJamie YoungSteven P. WilliamsLucas A. MaddalenaUltan McDermottMargaret AshcroftNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Luke W. Thomas Cinzia Esposito Rachel E. Morgan Stacey Price Jamie Young Steven P. Williams Lucas A. Maddalena Ultan McDermott Margaret Ashcroft Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
description	Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell viability in hypoxia are identified.
format	article
author	Luke W. Thomas Cinzia Esposito Rachel E. Morgan Stacey Price Jamie Young Steven P. Williams Lucas A. Maddalena Ultan McDermott Margaret Ashcroft
author_facet	Luke W. Thomas Cinzia Esposito Rachel E. Morgan Stacey Price Jamie Young Steven P. Williams Lucas A. Maddalena Ultan McDermott Margaret Ashcroft
author_sort	Luke W. Thomas
title	Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
title_short	Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
title_full	Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
title_fullStr	Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
title_full_unstemmed	Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
title_sort	genome-wide crispr/cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf0028ba8d264de48beb6836642740d8
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Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

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