Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

Thomas, Ashcroft and colleagues use genome-wide CRISPR/Cas9 screening under tumour-relevant metabolic conditions to identify genes that are essential in cancer. Mitochondrial gene essentiality is highlighted, and routes for regulating tumour cell viability in hypoxia are identified.

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Detalles Bibliográficos
Autores principales: Luke W. Thomas, Cinzia Esposito, Rachel E. Morgan, Stacey Price, Jamie Young, Steven P. Williams, Lucas A. Maddalena, Ultan McDermott, Margaret Ashcroft
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/bf0028ba8d264de48beb6836642740d8
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