Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)

ABSTRACT The role by which the gut microbiome influences host health (e.g., energy equilibrium and immune system) may be partly mediated by short-chain fatty acids, which are bacterial fermentation products from the dietary fibers. However, little is known about longitudinal changes in gut microbiom...

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Autores principales:	Lifeng Zhu, Mallory J. Suhr Van Haute, Haley R. Hassenstab, Caroline Smith, Devin J. Rose, Aaryn C. Mustoe, Andrew K. Benson, Jeffrey A. French
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	common marmosets cohabitation and social contact short-chain fatty acids sex difference Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/bf0053d35dab4222959629734930978d
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spelling	oai:doaj.org-article:bf0053d35dab4222959629734930978d2021-11-15T15:30:59ZFecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)10.1128/mSphere.00794-202379-5042https://doaj.org/article/bf0053d35dab4222959629734930978d2020-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00794-20https://doaj.org/toc/2379-5042ABSTRACT The role by which the gut microbiome influences host health (e.g., energy equilibrium and immune system) may be partly mediated by short-chain fatty acids, which are bacterial fermentation products from the dietary fibers. However, little is known about longitudinal changes in gut microbiome metabolites during cohabitation alongside social contact. In common marmosets (Callithrix jacchus), the gut microbiome community is influenced by social contact, as newly paired males and females develop convergent microbial profiles. Here, we monitored the dynamics of short-chain fatty acid concentrations in common marmoset feces from the prepairing (PRE) to postpairing (POST) stages. In males, we observed that the concentrations of acetate, propionate, isobutyrate, and isovalerate significantly increased in the POST stage compared to the PRE stage. However, no significant changes were found in females. We further found that the propionate concentration was significantly positively correlated with the abundance of Phascolarctobacterium in the male feces. Thus, the sex difference in the changes in the concentrations of short-chain fatty acids might be related to sex-biased gut microbiome transmission after pairing. We suggest that the significant changes in the gut microbiomes and some short-chain fatty acids of the common marmoset during cohabitation may contribute to physiological homeostasis during pairing. IMPORTANCE This study addressed a knowledge gap about longitudinal changes in the gut microbiome metabolites during animal pairing. This research in the laboratory common marmoset can control for the confounding factors such as diet and other environmental conditions. Phascolarctobacterium showed the highest contribution to the sex-biased transmission of the female to the male after pairing. Here, we observed the sex difference in the increase in short-chain fatty acid concentration in the feces of newly paired marmosets, which may be caused by the sex-biased gut microbiome transmission after pairing.Lifeng ZhuMallory J. Suhr Van HauteHaley R. HassenstabCaroline SmithDevin J. RoseAaryn C. MustoeAndrew K. BensonJeffrey A. FrenchAmerican Society for Microbiologyarticlecommon marmosetscohabitation and social contactshort-chain fatty acidssex differenceMicrobiologyQR1-502ENmSphere, Vol 5, Iss 5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	common marmosets cohabitation and social contact short-chain fatty acids sex difference Microbiology QR1-502
spellingShingle	common marmosets cohabitation and social contact short-chain fatty acids sex difference Microbiology QR1-502 Lifeng Zhu Mallory J. Suhr Van Haute Haley R. Hassenstab Caroline Smith Devin J. Rose Aaryn C. Mustoe Andrew K. Benson Jeffrey A. French Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)
description	ABSTRACT The role by which the gut microbiome influences host health (e.g., energy equilibrium and immune system) may be partly mediated by short-chain fatty acids, which are bacterial fermentation products from the dietary fibers. However, little is known about longitudinal changes in gut microbiome metabolites during cohabitation alongside social contact. In common marmosets (Callithrix jacchus), the gut microbiome community is influenced by social contact, as newly paired males and females develop convergent microbial profiles. Here, we monitored the dynamics of short-chain fatty acid concentrations in common marmoset feces from the prepairing (PRE) to postpairing (POST) stages. In males, we observed that the concentrations of acetate, propionate, isobutyrate, and isovalerate significantly increased in the POST stage compared to the PRE stage. However, no significant changes were found in females. We further found that the propionate concentration was significantly positively correlated with the abundance of Phascolarctobacterium in the male feces. Thus, the sex difference in the changes in the concentrations of short-chain fatty acids might be related to sex-biased gut microbiome transmission after pairing. We suggest that the significant changes in the gut microbiomes and some short-chain fatty acids of the common marmoset during cohabitation may contribute to physiological homeostasis during pairing. IMPORTANCE This study addressed a knowledge gap about longitudinal changes in the gut microbiome metabolites during animal pairing. This research in the laboratory common marmoset can control for the confounding factors such as diet and other environmental conditions. Phascolarctobacterium showed the highest contribution to the sex-biased transmission of the female to the male after pairing. Here, we observed the sex difference in the increase in short-chain fatty acid concentration in the feces of newly paired marmosets, which may be caused by the sex-biased gut microbiome transmission after pairing.
format	article
author	Lifeng Zhu Mallory J. Suhr Van Haute Haley R. Hassenstab Caroline Smith Devin J. Rose Aaryn C. Mustoe Andrew K. Benson Jeffrey A. French
author_facet	Lifeng Zhu Mallory J. Suhr Van Haute Haley R. Hassenstab Caroline Smith Devin J. Rose Aaryn C. Mustoe Andrew K. Benson Jeffrey A. French
author_sort	Lifeng Zhu
title	Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)
title_short	Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)
title_full	Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)
title_fullStr	Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)
title_full_unstemmed	Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)
title_sort	fecal short-chain fatty acid concentrations increase in newly paired male marmosets (<named-content content-type="genus-species">callithrix jacchus</named-content>)
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/bf0053d35dab4222959629734930978d
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Fecal Short-Chain Fatty Acid Concentrations Increase in Newly Paired Male Marmosets (<named-content content-type="genus-species">Callithrix jacchus</named-content>)

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