The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target

Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasio...

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Autores principales:	Junya Ke, Jiangfeng Ye, Mingqing Li, Zhiling Zhu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	matrix metalloproteinases endometriosis function potential value Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/bf028fd4eaf1406c93d00aa724c08e64
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spelling	oai:doaj.org-article:bf028fd4eaf1406c93d00aa724c08e642021-11-25T16:54:44ZThe Role of Matrix Metalloproteinases in Endometriosis: A Potential Target10.3390/biom111117392218-273Xhttps://doaj.org/article/bf028fd4eaf1406c93d00aa724c08e642021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1739https://doaj.org/toc/2218-273XEndometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions.Junya KeJiangfeng YeMingqing LiZhiling ZhuMDPI AGarticlematrix metalloproteinasesendometriosisfunctionpotential valueMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1739, p 1739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	matrix metalloproteinases endometriosis function potential value Microbiology QR1-502
spellingShingle	matrix metalloproteinases endometriosis function potential value Microbiology QR1-502 Junya Ke Jiangfeng Ye Mingqing Li Zhiling Zhu The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
description	Endometriosis is a condition that is influenced by hormones and involves stroma and glands being found outside the uterus; there are increases in proliferation, invasion, internal bleeding, and fibrosis. Matrix metalloproteinases (MMPs) have been suggested to be crucial in the progression of invasion. The MMP family includes calcium-dependent zinc-containing endopeptidases, some of which not only affect the process of cell invasion but also participate in other physiological and pathological processes, such as angiogenesis and fibrosis. MMPs act as downstream-targeted molecules and their expression can be regulated by numerous factors such as estrogen, oxidative stress, cytokines, and environmental contaminants. Given their unique roles in endometriosis, MMPs may become effective biomarkers of endometriosis in the future. In the present review, we summarize the current literature on MMPs regarding their classification, function, and potential value for endometriosis, which may contribute to our knowledge of MMPs and MMP-targeted interventions.
format	article
author	Junya Ke Jiangfeng Ye Mingqing Li Zhiling Zhu
author_facet	Junya Ke Jiangfeng Ye Mingqing Li Zhiling Zhu
author_sort	Junya Ke
title	The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_short	The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_full	The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_fullStr	The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_full_unstemmed	The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target
title_sort	role of matrix metalloproteinases in endometriosis: a potential target
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/bf028fd4eaf1406c93d00aa724c08e64
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The Role of Matrix Metalloproteinases in Endometriosis: A Potential Target

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