Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

Episodic memory consolidation requires activity in hippocampal area CA1. Here the authors report that pharmacogenetic inhibition of CA1 PV+ interneuron firing after fear learning blocks memory consolidation and disrupts associated enhancement in network oscillations and stabilization of functional c...

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Autores principales:	Nicolette Ognjanovski, Samantha Schaeffer, Jiaxing Wu, Sima Mofakham, Daniel Maruyama, Michal Zochowski, Sara J. Aton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf06b50d70464b4d859c582806ac7bb8
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spelling	oai:doaj.org-article:bf06b50d70464b4d859c582806ac7bb82021-12-02T14:41:09ZParvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation10.1038/ncomms150392041-1723https://doaj.org/article/bf06b50d70464b4d859c582806ac7bb82017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15039https://doaj.org/toc/2041-1723Episodic memory consolidation requires activity in hippocampal area CA1. Here the authors report that pharmacogenetic inhibition of CA1 PV+ interneuron firing after fear learning blocks memory consolidation and disrupts associated enhancement in network oscillations and stabilization of functional connectivity patterns.Nicolette OgnjanovskiSamantha SchaefferJiaxing WuSima MofakhamDaniel MaruyamaMichal ZochowskiSara J. AtonNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolette Ognjanovski Samantha Schaeffer Jiaxing Wu Sima Mofakham Daniel Maruyama Michal Zochowski Sara J. Aton Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
description	Episodic memory consolidation requires activity in hippocampal area CA1. Here the authors report that pharmacogenetic inhibition of CA1 PV+ interneuron firing after fear learning blocks memory consolidation and disrupts associated enhancement in network oscillations and stabilization of functional connectivity patterns.
format	article
author	Nicolette Ognjanovski Samantha Schaeffer Jiaxing Wu Sima Mofakham Daniel Maruyama Michal Zochowski Sara J. Aton
author_facet	Nicolette Ognjanovski Samantha Schaeffer Jiaxing Wu Sima Mofakham Daniel Maruyama Michal Zochowski Sara J. Aton
author_sort	Nicolette Ognjanovski
title	Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
title_short	Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
title_full	Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
title_fullStr	Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
title_full_unstemmed	Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
title_sort	parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bf06b50d70464b4d859c582806ac7bb8
work_keys_str_mv	AT nicoletteognjanovski parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation AT samanthaschaeffer parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation AT jiaxingwu parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation AT simamofakham parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation AT danielmaruyama parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation AT michalzochowski parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation AT sarajaton parvalbuminexpressinginterneuronscoordinatehippocampalnetworkdynamicsrequiredformemoryconsolidation
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Parvalbumin-expressing interneurons coordinate hippocampal network dynamics required for memory consolidation

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