Enhancer-associated H3K4 methylation safeguards in vitro germline competence

While inductive signals controlling germline specification are well characterized, the intrinsic factors that allow epiblast cells to respond to such signals remain largely unknown. Here the authors use in vitro differentiated primordial germ cells to show that partial retention of histone H3K4 mono...

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Autores principales:	Tore Bleckwehl, Giuliano Crispatzu, Kaitlin Schaaf, Patricia Respuela, Michaela Bartusel, Laura Benson, Stephen J. Clark, Kristel M. Dorighi, Antonio Barral, Magdalena Laugsch, Wilfred F. J. van IJcken, Miguel Manzanares, Joanna Wysocka, Wolf Reik, Álvaro Rada-Iglesias
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/bf07c5a2a44549a9aca337c37d7cef97
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spelling	oai:doaj.org-article:bf07c5a2a44549a9aca337c37d7cef972021-12-02T18:51:16ZEnhancer-associated H3K4 methylation safeguards in vitro germline competence10.1038/s41467-021-26065-62041-1723https://doaj.org/article/bf07c5a2a44549a9aca337c37d7cef972021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26065-6https://doaj.org/toc/2041-1723While inductive signals controlling germline specification are well characterized, the intrinsic factors that allow epiblast cells to respond to such signals remain largely unknown. Here the authors use in vitro differentiated primordial germ cells to show that partial retention of histone H3K4 monomethylation within relevant enhancers is important for germline competence and specification.Tore BleckwehlGiuliano CrispatzuKaitlin SchaafPatricia RespuelaMichaela BartuselLaura BensonStephen J. ClarkKristel M. DorighiAntonio BarralMagdalena LaugschWilfred F. J. van IJckenMiguel ManzanaresJoanna WysockaWolf ReikÁlvaro Rada-IglesiasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tore Bleckwehl Giuliano Crispatzu Kaitlin Schaaf Patricia Respuela Michaela Bartusel Laura Benson Stephen J. Clark Kristel M. Dorighi Antonio Barral Magdalena Laugsch Wilfred F. J. van IJcken Miguel Manzanares Joanna Wysocka Wolf Reik Álvaro Rada-Iglesias Enhancer-associated H3K4 methylation safeguards in vitro germline competence
description	While inductive signals controlling germline specification are well characterized, the intrinsic factors that allow epiblast cells to respond to such signals remain largely unknown. Here the authors use in vitro differentiated primordial germ cells to show that partial retention of histone H3K4 monomethylation within relevant enhancers is important for germline competence and specification.
format	article
author	Tore Bleckwehl Giuliano Crispatzu Kaitlin Schaaf Patricia Respuela Michaela Bartusel Laura Benson Stephen J. Clark Kristel M. Dorighi Antonio Barral Magdalena Laugsch Wilfred F. J. van IJcken Miguel Manzanares Joanna Wysocka Wolf Reik Álvaro Rada-Iglesias
author_facet	Tore Bleckwehl Giuliano Crispatzu Kaitlin Schaaf Patricia Respuela Michaela Bartusel Laura Benson Stephen J. Clark Kristel M. Dorighi Antonio Barral Magdalena Laugsch Wilfred F. J. van IJcken Miguel Manzanares Joanna Wysocka Wolf Reik Álvaro Rada-Iglesias
author_sort	Tore Bleckwehl
title	Enhancer-associated H3K4 methylation safeguards in vitro germline competence
title_short	Enhancer-associated H3K4 methylation safeguards in vitro germline competence
title_full	Enhancer-associated H3K4 methylation safeguards in vitro germline competence
title_fullStr	Enhancer-associated H3K4 methylation safeguards in vitro germline competence
title_full_unstemmed	Enhancer-associated H3K4 methylation safeguards in vitro germline competence
title_sort	enhancer-associated h3k4 methylation safeguards in vitro germline competence
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf07c5a2a44549a9aca337c37d7cef97
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Enhancer-associated H3K4 methylation safeguards in vitro germline competence

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