Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C.

Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C.

P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), restricting the penetration of various compounds. In other tissues, trafficking of Pgp from subcellular stores to the cell surface has been demonstrated and may constitute a rapid way of the cell to resp...

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Autores principales: Andreas Noack, Sandra Noack, Andrea Hoffmann, Katia Maalouf, Manuela Buettner, Pierre-Olivier Couraud, Ignacio A Romero, Babette Weksler, Dana Alms, Kerstin Römermann, Hassan Y Naim, Wolfgang Löscher
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/bf094d4172b244c1b86a85bd0fc2e8d5
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