Tooth loss and head and neck cancer: a meta-analysis of observational studies.

<h4>Background</h4>[corrected] Epidemiological studies have shown that tooth loss is associated with risk of head and neck cancer (HNC); however, the results were inconsistent. Therefore, we conducted a meta-analysis to ascertain the relationship between tooth loss and HNC.<h4>Meth...

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Autores principales:	Xian-Tao Zeng, Wei Luo, Wei Huang, Quan Wang, Yi Guo, Wei-Dong Leng
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf09c7b29655411981e5c3dd6ee5d229
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spelling	oai:doaj.org-article:bf09c7b29655411981e5c3dd6ee5d2292021-11-18T08:46:10ZTooth loss and head and neck cancer: a meta-analysis of observational studies.1932-620310.1371/journal.pone.0079074https://doaj.org/article/bf09c7b29655411981e5c3dd6ee5d2292013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260154/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>[corrected] Epidemiological studies have shown that tooth loss is associated with risk of head and neck cancer (HNC); however, the results were inconsistent. Therefore, we conducted a meta-analysis to ascertain the relationship between tooth loss and HNC.<h4>Methods</h4>We searched for relevant observational studies that tested the association between tooth loss and risk of HNC from PubMed and were conducted up to January 30, 2013. Data from the eligible studies were independently extracted by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis 2.2 software. Sensitivity and subgroup analyses were conducted to evaluate the influence of various inclusions. Publication bias was also detected.<h4>Results</h4>Ten articles involving one cohort and ten case-control studies were yielded. Based on random-effects meta-analysis, an association between tooth loss and HNC risk was identified [increased risk of 29% for 1 to 6 teeth loss (OR = 1.29, 95% CI = 0.52-3.20, p = 0.59), 58% for 6 to 15 teeth loss (OR = 1.58, 95% CI = 1.08-2.32, p = 0.02), 63% for 11+ teeth loss (OR = 1.63, 95% CI = 1.23-2.14, p<0.001), 72% for 15+ teeth loss (OR = 1.72, 95% CI = 1.26-2.36, p<0.001), and 89% for 20+ teeth loss (OR = 1.89, 95% CI = 1.27-2.80, p<0.001)]. The sensitivity analysis shows that the result was robust, and publication bias was not detected.<h4>Conclusions</h4>Based on the current evidence, tooth loss is probably a significant and dependent risk factor of HNC, which may have a dose-response effect. People who lost six or more teeth should pay attention to symptoms of HNC, and losing 11 teeth or 15 teeth may be the threshold.Xian-Tao ZengWei LuoWei HuangQuan WangYi GuoWei-Dong LengPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79074 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xian-Tao Zeng Wei Luo Wei Huang Quan Wang Yi Guo Wei-Dong Leng Tooth loss and head and neck cancer: a meta-analysis of observational studies.
description	<h4>Background</h4>[corrected] Epidemiological studies have shown that tooth loss is associated with risk of head and neck cancer (HNC); however, the results were inconsistent. Therefore, we conducted a meta-analysis to ascertain the relationship between tooth loss and HNC.<h4>Methods</h4>We searched for relevant observational studies that tested the association between tooth loss and risk of HNC from PubMed and were conducted up to January 30, 2013. Data from the eligible studies were independently extracted by two authors. The meta-analysis was performed using the Comprehensive Meta-Analysis 2.2 software. Sensitivity and subgroup analyses were conducted to evaluate the influence of various inclusions. Publication bias was also detected.<h4>Results</h4>Ten articles involving one cohort and ten case-control studies were yielded. Based on random-effects meta-analysis, an association between tooth loss and HNC risk was identified [increased risk of 29% for 1 to 6 teeth loss (OR = 1.29, 95% CI = 0.52-3.20, p = 0.59), 58% for 6 to 15 teeth loss (OR = 1.58, 95% CI = 1.08-2.32, p = 0.02), 63% for 11+ teeth loss (OR = 1.63, 95% CI = 1.23-2.14, p<0.001), 72% for 15+ teeth loss (OR = 1.72, 95% CI = 1.26-2.36, p<0.001), and 89% for 20+ teeth loss (OR = 1.89, 95% CI = 1.27-2.80, p<0.001)]. The sensitivity analysis shows that the result was robust, and publication bias was not detected.<h4>Conclusions</h4>Based on the current evidence, tooth loss is probably a significant and dependent risk factor of HNC, which may have a dose-response effect. People who lost six or more teeth should pay attention to symptoms of HNC, and losing 11 teeth or 15 teeth may be the threshold.
format	article
author	Xian-Tao Zeng Wei Luo Wei Huang Quan Wang Yi Guo Wei-Dong Leng
author_facet	Xian-Tao Zeng Wei Luo Wei Huang Quan Wang Yi Guo Wei-Dong Leng
author_sort	Xian-Tao Zeng
title	Tooth loss and head and neck cancer: a meta-analysis of observational studies.
title_short	Tooth loss and head and neck cancer: a meta-analysis of observational studies.
title_full	Tooth loss and head and neck cancer: a meta-analysis of observational studies.
title_fullStr	Tooth loss and head and neck cancer: a meta-analysis of observational studies.
title_full_unstemmed	Tooth loss and head and neck cancer: a meta-analysis of observational studies.
title_sort	tooth loss and head and neck cancer: a meta-analysis of observational studies.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/bf09c7b29655411981e5c3dd6ee5d229
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Tooth loss and head and neck cancer: a meta-analysis of observational studies.

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