Temporal production signals in parietal cortex.

We often perform movements and actions on the basis of internal motivations and without any explicit instructions or cues. One common example of such behaviors is our ability to initiate movements solely on the basis of an internally generated sense of the passage of time. In order to isolate the ne...

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Autores principales:	Blaine A Schneider, Geoffrey M Ghose
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/bf0ba556512f4512a56c1edd5f6d58fb
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spelling	oai:doaj.org-article:bf0ba556512f4512a56c1edd5f6d58fb2021-11-18T05:37:23ZTemporal production signals in parietal cortex.1544-91731545-788510.1371/journal.pbio.1001413https://doaj.org/article/bf0ba556512f4512a56c1edd5f6d58fb2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23118614/pdf/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885We often perform movements and actions on the basis of internal motivations and without any explicit instructions or cues. One common example of such behaviors is our ability to initiate movements solely on the basis of an internally generated sense of the passage of time. In order to isolate the neuronal signals responsible for such timed behaviors, we devised a task that requires nonhuman primates to move their eyes consistently at regular time intervals in the absence of any external stimulus events and without an immediate expectation of reward. Despite the lack of sensory information, we found that animals were remarkably precise and consistent in timed behaviors, with standard deviations on the order of 100 ms. To examine the potential neural basis of this precision, we recorded from single neurons in the lateral intraparietal area (LIP), which has been implicated in the planning and execution of eye movements. In contrast to previous studies that observed a build-up of activity associated with the passage of time, we found that LIP activity decreased at a constant rate between timed movements. Moreover, the magnitude of activity was predictive of the timing of the impending movement. Interestingly, this relationship depended on eye movement direction: activity was negatively correlated with timing when the upcoming saccade was toward the neuron's response field and positively correlated when the upcoming saccade was directed away from the response field. This suggests that LIP activity encodes timed movements in a push-pull manner by signaling for both saccade initiation towards one target and prolonged fixation for the other target. Thus timed movements in this task appear to reflect the competition between local populations of task relevant neurons rather than a global timing signal.Blaine A SchneiderGeoffrey M GhosePublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 10, Iss 10, p e1001413 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Blaine A Schneider Geoffrey M Ghose Temporal production signals in parietal cortex.
description	We often perform movements and actions on the basis of internal motivations and without any explicit instructions or cues. One common example of such behaviors is our ability to initiate movements solely on the basis of an internally generated sense of the passage of time. In order to isolate the neuronal signals responsible for such timed behaviors, we devised a task that requires nonhuman primates to move their eyes consistently at regular time intervals in the absence of any external stimulus events and without an immediate expectation of reward. Despite the lack of sensory information, we found that animals were remarkably precise and consistent in timed behaviors, with standard deviations on the order of 100 ms. To examine the potential neural basis of this precision, we recorded from single neurons in the lateral intraparietal area (LIP), which has been implicated in the planning and execution of eye movements. In contrast to previous studies that observed a build-up of activity associated with the passage of time, we found that LIP activity decreased at a constant rate between timed movements. Moreover, the magnitude of activity was predictive of the timing of the impending movement. Interestingly, this relationship depended on eye movement direction: activity was negatively correlated with timing when the upcoming saccade was toward the neuron's response field and positively correlated when the upcoming saccade was directed away from the response field. This suggests that LIP activity encodes timed movements in a push-pull manner by signaling for both saccade initiation towards one target and prolonged fixation for the other target. Thus timed movements in this task appear to reflect the competition between local populations of task relevant neurons rather than a global timing signal.
format	article
author	Blaine A Schneider Geoffrey M Ghose
author_facet	Blaine A Schneider Geoffrey M Ghose
author_sort	Blaine A Schneider
title	Temporal production signals in parietal cortex.
title_short	Temporal production signals in parietal cortex.
title_full	Temporal production signals in parietal cortex.
title_fullStr	Temporal production signals in parietal cortex.
title_full_unstemmed	Temporal production signals in parietal cortex.
title_sort	temporal production signals in parietal cortex.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/bf0ba556512f4512a56c1edd5f6d58fb
work_keys_str_mv	AT blaineaschneider temporalproductionsignalsinparietalcortex AT geoffreymghose temporalproductionsignalsinparietalcortex
_version_	1718424876820201472

Temporal production signals in parietal cortex.

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