Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications

Abstract Dicarboxylic amino acid-based surfactants (N-dodecyl derivatives of -aminomalonate, -aspartate, and -glutamate) in combination with hexadecyltrimethylammonium bromide (HTAB) form a variety of aggregates. Composition and concentration-dependent mixtures exhibit liquid crystal, gel, precipita...

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Autores principales:	Manas Barai, Emili Manna, Habiba Sultana, Manas Kumar Mandal, Kartik Chandra Guchhait, Tuhin Manna, Anuttam Patra, Chien-Hsiang Chang, Parikshit Moitra, Chandradipa Ghosh, Anna-Carin Larsson, Santanu Bhattacharya, Amiya Kumar Panda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf0cd4feee0e4824bbfe65ac71d8bfeb
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spelling	oai:doaj.org-article:bf0cd4feee0e4824bbfe65ac71d8bfeb2021-12-02T16:24:59ZMicro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications10.1038/s41598-021-94777-22045-2322https://doaj.org/article/bf0cd4feee0e4824bbfe65ac71d8bfeb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94777-2https://doaj.org/toc/2045-2322Abstract Dicarboxylic amino acid-based surfactants (N-dodecyl derivatives of -aminomalonate, -aspartate, and -glutamate) in combination with hexadecyltrimethylammonium bromide (HTAB) form a variety of aggregates. Composition and concentration-dependent mixtures exhibit liquid crystal, gel, precipitate, and clear isotropic phases. Liquid crystalline patterns, formed by surfactant mixtures, were identified by polarizing optical microscopy. FE-SEM studies reveal the existence of surface morphologies of different mixed aggregates. Phase transition and associated weight loss were found to depend on the composition where thermotropic behaviours were revealed through combined differential scanning calorimetry and thermogravimetric studies. Systems comprising more than 60 mol% HTAB demonstrate shear-thinning behaviour. Gels cause insignificant toxicity to human peripheral lymphocytes and irritation to bare mouse skin; they do not display the symptoms of cutaneous irritation, neutrophilic invasion, and inflammation (erythema, edema, and skin thinning) as evidenced by cumulative irritancy index score. Gels also exhibit substantial antibacterial effects on Staphylococcus aureus, a potent causative agent of skin and soft tissue infections, suggesting its possible application as a vehicle for topical dermatological drug delivery.Manas BaraiEmili MannaHabiba SultanaManas Kumar MandalKartik Chandra GuchhaitTuhin MannaAnuttam PatraChien-Hsiang ChangParikshit MoitraChandradipa GhoshAnna-Carin LarssonSantanu BhattacharyaAmiya Kumar PandaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manas Barai Emili Manna Habiba Sultana Manas Kumar Mandal Kartik Chandra Guchhait Tuhin Manna Anuttam Patra Chien-Hsiang Chang Parikshit Moitra Chandradipa Ghosh Anna-Carin Larsson Santanu Bhattacharya Amiya Kumar Panda Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
description	Abstract Dicarboxylic amino acid-based surfactants (N-dodecyl derivatives of -aminomalonate, -aspartate, and -glutamate) in combination with hexadecyltrimethylammonium bromide (HTAB) form a variety of aggregates. Composition and concentration-dependent mixtures exhibit liquid crystal, gel, precipitate, and clear isotropic phases. Liquid crystalline patterns, formed by surfactant mixtures, were identified by polarizing optical microscopy. FE-SEM studies reveal the existence of surface morphologies of different mixed aggregates. Phase transition and associated weight loss were found to depend on the composition where thermotropic behaviours were revealed through combined differential scanning calorimetry and thermogravimetric studies. Systems comprising more than 60 mol% HTAB demonstrate shear-thinning behaviour. Gels cause insignificant toxicity to human peripheral lymphocytes and irritation to bare mouse skin; they do not display the symptoms of cutaneous irritation, neutrophilic invasion, and inflammation (erythema, edema, and skin thinning) as evidenced by cumulative irritancy index score. Gels also exhibit substantial antibacterial effects on Staphylococcus aureus, a potent causative agent of skin and soft tissue infections, suggesting its possible application as a vehicle for topical dermatological drug delivery.
format	article
author	Manas Barai Emili Manna Habiba Sultana Manas Kumar Mandal Kartik Chandra Guchhait Tuhin Manna Anuttam Patra Chien-Hsiang Chang Parikshit Moitra Chandradipa Ghosh Anna-Carin Larsson Santanu Bhattacharya Amiya Kumar Panda
author_facet	Manas Barai Emili Manna Habiba Sultana Manas Kumar Mandal Kartik Chandra Guchhait Tuhin Manna Anuttam Patra Chien-Hsiang Chang Parikshit Moitra Chandradipa Ghosh Anna-Carin Larsson Santanu Bhattacharya Amiya Kumar Panda
author_sort	Manas Barai
title	Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
title_short	Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
title_full	Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
title_fullStr	Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
title_full_unstemmed	Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
title_sort	micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/bf0cd4feee0e4824bbfe65ac71d8bfeb
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Micro-structural investigations on oppositely charged mixed surfactant gels with potential dermal applications

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