Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney

Abstract The renal vasculature is required for blood filtration, blood pressure regulation, and pH maintenance, as well as other specialised kidney functions. Yet, despite its importance, many aspects of its development are poorly understood. To provide a detailed spatiotemporal analysis of kidney v...

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Autores principales:	David A. D. Munro, Peter Hohenstein, Jamie A. Davies
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/bf13a0912bcc4eba9d0bb867c36a3111
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spelling	oai:doaj.org-article:bf13a0912bcc4eba9d0bb867c36a31112021-12-02T12:30:54ZCycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney10.1038/s41598-017-03808-42045-2322https://doaj.org/article/bf13a0912bcc4eba9d0bb867c36a31112017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03808-4https://doaj.org/toc/2045-2322Abstract The renal vasculature is required for blood filtration, blood pressure regulation, and pH maintenance, as well as other specialised kidney functions. Yet, despite its importance, many aspects of its development are poorly understood. To provide a detailed spatiotemporal analysis of kidney vascularisation, we collected images of embryonic mouse kidneys at various developmental time-points. Here we describe the first stages of kidney vascularisation and demonstrate that polygonal networks of vessels (endothelial plexuses) form in cycles at the periphery of the kidney. We show that kidney vascularisation initiates at E11, when vessels connected to the embryonic circulation form a ring around the ureteric bud. From E13.5, endothelial plexuses organise around populations of cap mesenchymal and ureteric bud cells in a cyclical, predictable manner. Specifically, as the ureteric bud bifurcates, endothelia form across the bifurcation site as the cap mesenchyme splits. The plexuses are vascular, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the renal artery. Our results are a major step towards understanding how the global architecture of the renal vasculature is achieved.David A. D. MunroPeter HohensteinJamie A. DaviesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David A. D. Munro Peter Hohenstein Jamie A. Davies Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
description	Abstract The renal vasculature is required for blood filtration, blood pressure regulation, and pH maintenance, as well as other specialised kidney functions. Yet, despite its importance, many aspects of its development are poorly understood. To provide a detailed spatiotemporal analysis of kidney vascularisation, we collected images of embryonic mouse kidneys at various developmental time-points. Here we describe the first stages of kidney vascularisation and demonstrate that polygonal networks of vessels (endothelial plexuses) form in cycles at the periphery of the kidney. We show that kidney vascularisation initiates at E11, when vessels connected to the embryonic circulation form a ring around the ureteric bud. From E13.5, endothelial plexuses organise around populations of cap mesenchymal and ureteric bud cells in a cyclical, predictable manner. Specifically, as the ureteric bud bifurcates, endothelia form across the bifurcation site as the cap mesenchyme splits. The plexuses are vascular, carry erythrocytes, are enclosed within a basement membrane, and can always be traced back to the renal artery. Our results are a major step towards understanding how the global architecture of the renal vasculature is achieved.
format	article
author	David A. D. Munro Peter Hohenstein Jamie A. Davies
author_facet	David A. D. Munro Peter Hohenstein Jamie A. Davies
author_sort	David A. D. Munro
title	Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
title_short	Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
title_full	Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
title_fullStr	Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
title_full_unstemmed	Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
title_sort	cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/bf13a0912bcc4eba9d0bb867c36a3111
work_keys_str_mv	AT davidadmunro cyclesofvascularplexusformationwithinthenephrogeniczoneofthedevelopingmousekidney AT peterhohenstein cyclesofvascularplexusformationwithinthenephrogeniczoneofthedevelopingmousekidney AT jamieadavies cyclesofvascularplexusformationwithinthenephrogeniczoneofthedevelopingmousekidney
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Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney

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